Question:
Niacin sure upsets my stomach… taking 400 mgs a day so far.. doc wants me to go to 2000 mgs daily.. got high chloresterol…genetic I think. also taking Zocor, am 54 only acouple months now.
For what it’s worth, I’ve been taking 3,000 mg (that’s right, 3 grams) of niacin daily (three divided doses) for a year now to control cholesterol. My physician approves, monitors for liver function, and we find it controls my total cholesterol better than Zocor, and raises my HDL cholesterol which Zocor did not do. I am not now taking Zocor or any other statin drug. I had minimal flushing for about two months, none thereafter. I got a whopping case of a skin rash, which abated after about three weeks (I didn’t stop the niacin) and it has not returned.
Response:
Dr. Weil mentions "flush-free" aka "inositol-bound" niacin (aka inositol hexanicotinate) as the only type he would recommend for the dosage levels necessary for cholesterol reduction.
Is this the same as timed-release niacin? My physician insisted that I NOT take the timed release niacin in high doses, because it has a much higher incidence of liver function changes than the stuff which is not timed release.
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<<<Is this the same as timed-release niacin? My physician insisted that I NOT take the timed release niacin in high doses, because it has a much higher incidence of liver function changes than the stuff which is not timed release. This is correct. The literature now shows that timed-release niacin is tough on your liver. Stick with the regular dose, and increase it slowly throughout the month and your body will adapt. Stop whining about Chiropractic research and find it on MEDLINE: http://www.ncbi.nlm.nih.gov/PubMed/ RPG Greyhawk: http://members.aol.com/emirikol7——-
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I read recently about a substance that can modulate the vasodilating effect of niacin, but I cant remember what it is. Can anybody help me out?
Probably aspirin — but I think you have to take at least one a day to keep the niacin flush away. Apparently, changing one’s EFA balance — notably by taking GLA supplements or extra omega-3’s — can also modulate niacin’s vasoldilating effect, but I can’t remember in which direction(s).
Syd
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<<<Is this the same as timed-release niacin? My physician insisted that I NOT take the timed release niacin in high doses, because it has a much higher incidence of liver function changes than the stuff which is not timed release. This is correct. The literature now shows that timed-release niacin is tough on your liver. Stick with the regular dose, and increase it slowly throughout the month and your body will adapt.
No, the inositol hexaniacinate form of niacin isn’t the same as slow-release niacin. It’s a supposedly safer compound of niacin, and it isn’t slow release. – Hide quoted text — Show quoted text –
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: Is a dose of 750mg of niacin daily, in divided doses, going : to cause any liver problems? Or is 1g the starting point?
My physician had me on 4,000 mg daily for several years. My liver enzymes were slightly elevated during this time. I have taken 2,000 mg daily for many years now. Liver enzymes are normal with this dose. Check the orthomolecular sites. They have alot of info about Niacin. Judith
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– Hide quoted text — Show quoted text – : Is a dose of 750mg of niacin daily, in divided doses, going : to cause any liver problems? Or is 1g the starting point? : : Most professionals would caution against anything _near_ this amount. Hathcock, "Quantitative Evaluation of Vitamin Safety", from _Pharmacy Times_, pp. 104-113 (1985): "Niacin intakes up to 1,000 mg as nicotinic acid appear to be completely safe." Bryan
I disagree that it is completely safe. I developed a sever case of Acanthosis Nigricans and had to stop using it altogether.
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Vit C should do a better job of lowering cholesterol than does niacin.
My experience of taking Vitamin C would suggest that it does diddly in altering cholesterol levels. Nicotinic Acid ( niacin ) is a different story. Bye,
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I read recently about a substance that can modulate the vasodilating effect of niacin, but I cant remember what it is. Can anybody help me out? Stop whining about Chiropractic research and find it on MEDLINE: http://www.ncbi.nlm.nih.gov/PubMed/ RPG Greyhawk: http://members.aol.com/emirikol7——-
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Vit C should do a better job of lowering cholesterol than does niacin. Personally, I’d recommend Garlic. Niacin is a possibility (though I don’t need it), and I already take the Vitamin C. Eric Devotee of Dr. Andrew Weil’s books: _8 Weeks To Optimum Health_ and _Spontaneous Healing_
Niacin sure upsets my stomach… taking 400 mgs a day so far.. doc wants me to go to 2000 mgs daily.. got high chloresterol…genetic I think. also taking Zocor, am 54 only acouple months now.
Response:
- Hide quoted text — Show quoted text – : Is a dose of 750mg of niacin daily, in divided doses, going : to cause any liver problems? Or is 1g the starting point? : : Most professionals would caution against anything _near_ this amount. Hathcock, "Quantitative Evaluation of Vitamin Safety", from _Pharmacy Times_, pp. 104-113 (1985): "Niacin intakes up to 1,000 mg as nicotinic acid appear to be completely safe." Bryan I just read that Niacin should only be taken when a persons serum cholesterol does not come down from diet. It should be taken only under the supervision of a physician because it can cause serious disturbances in liver function. It should not be taken any higher than 500 mg. check out cgi.pathfinder.com/drweil/vitaminprofiler for more information. J9
Vit C should do a better job of lowering cholesterol than does niacin. You should all be aware in this niacin thing that free niacin is generally not available in food, although ultimately the conversion is made to niacin. No one can intelligently speculate on the safety issue. Virtually every doctor/nutritionist will mention the alteration of liver function with high niacin. You can gamble if you want, and perhaps luck out if this alteration happens to be beneficial. But like genetic mutation, 99.9999% of the time it is _bad_. Just be glad that these niacin experimenters and self-styled chemists don’t build rocketships or airplanes. — Delivering God’s Messages on Post-Purchase Neglect Syndrome (PPNS), Physical Concepts & HoloBarre Fitness/Stretching Systems, NY Facts–plenty Synthesis–glorious Nice bodies–nice, but irrelevant
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: : Hathcock, "Quantitative Evaluation of Vitamin Safety", : from _Pharmacy Times_, pp. 104-113 (1985): : "Niacin intakes up to 1,000 mg as nicotinic acid appear to be : completely safe." : : I just read that Niacin should only be taken when a persons serum : cholesterol does not come down from diet. What you read only refers to its use as a cholesterol lowering agent. It’s not particularly relevant to this main discussion because we’re discussing the safe levels of niacin usage *per se*. For ANY use. : …It should be taken only under : the supervision of a physician because it can cause serious disturbances : in liver function. Yes, but only above certain safe levels, of course. The question is, what are those safe levels? : It should not be taken any higher than 500 mg. I think this must be an older, more conservative estimate of safe levels. Like back in the olden days when we were warned about vitamin C usage leading to spontaneous abortions, kidney stones, and B12 destruction. I’d put a little more credence in Hathcock’s analysis, frankly. Bryan
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- Hide quoted text — Show quoted text – : from _Pharmacy Times_, pp. 104-113 (1985): : "Niacin intakes up to 1,000 mg as nicotinic acid appear to be : completely safe." : : They might be for "typical" people, with "typical" livers. : I wouldn’t bet that my typical liver today would still be : typical after six months of 1,000 mg a day of B-3. A rather cryptic remark. Can you spell out exactly what you mean instead of using insinuations? Do you think there would be some irreversible and negative effects from 1,000 mg a day? Or what? : Bill W, co-founder of AA took niacin at the rate of 2,000 mg : a day for depression from the early sixties til his death of : Emphysema many years later. This is from a book by his non- : alcoholic secretary Nell Wing. And your point is …? You speak in riddles, my friend! Are you accusing his niacin intake of causing his emphysema? Do you have any proof of this unusual claim? Bryan
Dear whomever, It would seem logical that taking alot of one vitamin may interupt the balance of other corresponding vitamins in your body. We are made a very complex makeup and I definitely would never suggest this. See a physician and last but not least the hunt and peck method just does not work. WHY???? SYNERGY. Sincerley, Ken
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: <<snip : Hathcock, "Quantitative Evaluation of Vitamin Safety", : from _Pharmacy Times_, pp. 104-113 (1985): : "Niacin intakes up to 1,000 mg as nicotinic acid appear to be : completely safe." : : They might be for "typical" people, with "typical" livers. : I wouldn’t bet that my typical liver today would still be : typical after six months of 1,000 mg a day of B-3. A rather cryptic remark. Can you spell out exactly what you mean instead of using insinuations? Do you think there would be some irreversible and negative effects from 1,000 mg a day? Or what? : Bill W, co-founder of AA took niacin at the rate of 2,000 mg : a day for depression from the early sixties til his death of : Emphysema many years later. This is from a book by his non- : alcoholic secretary Nell Wing. And your point is …? You speak in riddles, my friend! Are you accusing his niacin intake of causing his emphysema? Do you have any proof of this unusual claim? Bryan
Response:
- Hide quoted text — Show quoted text – : Is a dose of 750mg of niacin daily, in divided doses, going : to cause any liver problems? Or is 1g the starting point? : : Most professionals would caution against anything _near_ this amount. Hathcock, "Quantitative Evaluation of Vitamin Safety", from _Pharmacy Times_, pp. 104-113 (1985): "Niacin intakes up to 1,000 mg as nicotinic acid appear to be completely safe." Bryan
I just read that Niacin should only be taken when a persons serum cholesterol does not come down from diet. It should be taken only under the supervision of a physician because it can cause serious disturbances in liver function. It should not be taken any higher than 500 mg. check out cgi.pathfinder.com/drweil/vitaminprofiler for more information. J9
Response:
- Hide quoted text — Show quoted text – : Is a dose of 750mg of niacin daily, in divided doses, going : to cause any liver problems? Or is 1g the starting point? : : Most professionals would caution against anything _near_ this amount. Hathcock, "Quantitative Evaluation of Vitamin Safety", from _Pharmacy Times_, pp. 104-113 (1985): "Niacin intakes up to 1,000 mg as nicotinic acid appear to be completely safe." Bryan I disagree that it is completely safe. I developed a sever case of Acanthosis Nigricans and had to stop using it altogether.
Dear Interested; The RDA for niacin is 19 mg. The Colgan Institute uses 30-100 mg mostly as nicotinamide. In the niacin form, above 30 mg causes vascular dialation with flushing, burning and itching, the niacin flush. Apart from that discomfort, toxicity is low up to 1,000 mg per day. Have a great day Ken
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1000 mg/day of crystalline niacin is the lowest dose that helps. There are some people that do develop hepatitis using niacin. If you choose to use niacin then have your liver enzymes checked every year. Talk to your physician before taking niacin. Trust that this information is more informative. says… – Hide quoted text — Show quoted text – : <<snip : Hathcock, "Quantitative Evaluation of Vitamin Safety", : from _Pharmacy Times_, pp. 104-113 (1985): : "Niacin intakes up to 1,000 mg as nicotinic acid appear to be : completely safe." : : They might be for "typical" people, with "typical" livers. : I wouldn’t bet that my typical liver today would still be : typical after six months of 1,000 mg a day of B-3. A rather cryptic remark. Can you spell out exactly what you mean instead of using insinuations? Do you think there would be some irreversible and negative effects from 1,000 mg a day? Or what? : Bill W, co-founder of AA took niacin at the rate of 2,000 mg : a day for depression from the early sixties til his death of : Emphysema many years later. This is from a book by his non- : alcoholic secretary Nell Wing. And your point is …? You speak in riddles, my friend! Are you accusing his niacin intake of causing his emphysema? Do you have any proof of this unusual claim? Bryan
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Most professionals would caution against anything _near_ this
amount. Lifer’s, however, will have you taking so much niacin you could run around naked in the North Pole, wet from a shower, and not feel the cold.
Yes! You remind me of Pearson and Shaw recommending sex while taking large doses of niacin. What, I said? You like to have sex while feeling like you’ve just been 3rd degree sunburned? No wonder the leather costumes. It would seem then, that Big Momma Nature had not intended boucou niacin flushes, unless, of course, you are using them as
sexual aids, as I once did, inadvertantly.<< What? You’re into that? I’m agreeing more with your idea of torturing those small poodles with the niacin flush. And other worse annoyances. Pekinese.
Response:
: Is a dose of 750mg of niacin daily, in divided doses, going : to cause any liver problems? Or is 1g the starting point? : : Most professionals would caution against anything _near_ this amount. Hathcock, "Quantitative Evaluation of Vitamin Safety", from _Pharmacy Times_, pp. 104-113 (1985): "Niacin intakes up to 1,000 mg as nicotinic acid appear to be completely safe." Bryan
Response:
- Hide quoted text — Show quoted text – : Is a dose of 750mg of niacin daily, in divided doses, going : to cause any liver problems? Or is 1g the starting point? : : Most professionals would caution against anything _near_ this amount. Hathcock, "Quantitative Evaluation of Vitamin Safety", from _Pharmacy Times_, pp. 104-113 (1985): "Niacin intakes up to 1,000 mg as nicotinic acid appear to be completely safe." Bryan
They might be for "typical" people, with "typical" livers. I wouldn’t bet that my typical liver today would still be typical after six months of 1,000 mg a day of B-3. Bill W, co-founder of AA took niacin at the rate of 2,000 mg a day for depression from the early sixties til his death of Emphysema many years later. This is from a book by his non- alcoholic secretary Nell Wing. Dr Abram Hoffer <sp has been using mega dose niacin to treat Schizophrenia for more than thirty years, but all references I have seen recommended that liver function be monitored for doses in the range above 500 mg, to imply that is a sage dose for everyone. TW Morey Not a Doc
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Is a dose of 750mg of niacin daily, in divided doses, going to cause any liver problems? Or is 1g the starting point? Any info appreciated. Thanks…
Most professionals would caution against anything _near_ this amount. Lifer’s, however, will have you taking so much niacin you could run around naked in the North Pole, wet from a shower, and not feel the cold. If the intention of all this niacin supplementation is cholesterol reduction, you are much better off with Vitamin C, which has a known and direct role in cholesterol degradation. Most people don’t realize that most niacin in food is not available as free niacin but as NAD or some other bound form, which is eventually converted to niacin (or niacinamide, or some ping-ponging back and forth). It would seem then, that Big Momma Nature had not intended boucou niacin flushes, unless, of course, you are using them as sexual aids, as I once did, inadvertantly. In fact, let me tell you the story…. — If anything should be given 750 mg of Niacin, it should be one of those god-awful toy poodles. Give it something to really yap about…. Physical Concepts & HoloBarre Fitness Systems, NY Facts–cheap Synthesis–glorious Nice bodies–nice, but irrelevant
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Is a dose of 750mg of niacin daily, in divided doses, going to cause any liver problems? Or is 1g the starting point? Any info appreciated. Thanks…
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Believe the toxic level to be much higher than 1 gram, as I took 1-2 grams daily for years with no ill effects. – Hide quoted text — Show quoted text – Is a dose of 750mg of niacin daily, in divided doses, going to cause any liver problems? Or is 1g the starting point?
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