Posts belonging to Category 'Pregnancy Drug Category Asacol'

short post need help

Question:

I am in the middle of a terrible miagraine attack : ( this is gonna be quick as my head is fixing to splatter all over this computer.  I am trying to get preg doc took me off everything for headache today called me in tyelnol # 3 with codiene as this is safer to take during early preg. Anyone take this before? does it help? drawbacks?

Well, it didn’t help my migraines but it did help me sleep.  In my case, that is all codiene or demerol ever do for my pain.  But since I spent a good amount of my second pregnancy in severe pain with throwing up, breaking the cycle could sometimes be accomplished by ‘drugged sleep’. Were you taking preventatives?  I think inderal (a beta blocker) can be used while pregnant (I seem to recall that this was the only preventative anyone I know has taken while pregnant). The jury is out on caffiene and pregnancy.  It does help my migraines when I don’t intake it regularly so aspirin free excedrin was my first line of defense while pregnant.  Then I used tylenol #3 (tylenol with codiene).  I also had several heavy duty demerol shots.  I had a rough pregnancy the second time but no migraines the first time so it can vary.  I got pregnant 6 months after going off the pill the first time and my migraines hadn’t really come back before I got pregnant.  The second time, I was just starting into a bad patch when I got pregnant. That one didn’t end until I went on inderal for 8-10 months (my doctor didn’t offer it to me until after I had the baby but the baby is almost 9 years old now :-)  I also wonder about the irregular sleep I had then. I had a rough pregnancy anyway, Chris’s migraines were fairly bad (he’s 4 years 4 days older than his sister), and I had some pretty hefty money worries while pregnant.  Sleep irregularities can trigger mine and if they continue for long enough, can cause a horrible pain cycle for me. Georgia  Get your FREE web-based e-mail and newsgroup access at:                 http://MailAndNews.com  Create a new mailbox, or access your existing IMAP4 or  POP3 mailbox from anywhere with just a web browser.

Response:

I am in the middle of a terrible miagraine attack : ( this is gonna be quick as my head is fixing to splatter all over this computer.  I am trying to get preg doc took me off everything for headache today called me in tyelnol # 3 with codiene as this is safer to take during early preg. Anyone take this before? does it help? drawbacks? thanks

Response:

I took Tylenol #3 when I was pregnant because I pulled all the muscles in my back.  I was 6 months pregnant at the time.  The ER doc assured me all would be fine.  Everything turned out great. Lisa

Response:

Inderal is rated pregnancy category C.  ". . .in rats. . . . At doses of 150 mg/kg/day ( 10 times the maximum recommended human daily dose of propranolol on a weight basis), but not at doses of 80 mg/kg/day, treatment was associated with embryotoxicity (reduced litter size and increase resorption sites) as well as neonatal toxicity (deaths)."  Similar doses in rabbits caused no problems.   "There are no adequate and well-controlled trials in women.  Intrauterine growth retardation has been reported in neonates whose mothers received propranolol during pregnancy."  It is not clearly dangerous, buit there are hints that it might be. Magnesium is safe.  It is often used to treat complications of pregnancy. Verapamil, which is also used as a prophylactic, is also Category C, as is Elavil (amitriptyline). Wellbutrin is Category B — animal studies have shown no evidence of problem.  That is about as good as it gets for most drugs, since controlled trials in pregnant women carry high ethical and liability risks. Opiates (like codeine) are safe so far as fetal wastage (miscarriage) or abnormality is concerned.  If very large daily doses are being used in the weeks before delivery, there is a risk of addiction in the newborn, but that can be managed if the pediatrics team is alerted.  It is somewhat unlikely that you would be taking doses large enough to cause that, but it is worth watching.

– Hide quoted text — Show quoted text – I am in the middle of a terrible miagraine attack : ( this is gonna be quick as my head is fixing to splatter all over this computer.  I am trying to get preg doc took me off everything for headache today called me in tyelnol # 3 with codiene as this is safer to take during early preg. Anyone take this before? does it help? drawbacks? thanks

Response:

Any info on Trazodone?

Question:

Hi saw my Pdoc today. He prescribed trazodone to help with insomnia? Does anyone have knowledge of this drug? He mentioned prolonged erection as a possible side effect. Whats the story….Thanks  I will feel better before starting this to know more…..Fry

Response:

well, well, well. Trazodone is one of the older antidepressants, a tricyclic one I think. Also known as Desyrel.  I have been on it before.  And it was also for insomnia.  I got the impression it is prescribed for the side effect of sleepiness more than its anti depressant properties. But I just looked it up at www.medscape.com/druginfo  and you are right, this is a possible side effect and a very serious one it seems.  I never noticed that info before, but maybe I just didn’t pay attention cause I am a woman. but I have to say, I have never heard personally of any man who has experienced this. I would definitely read up on it, check www.rxlist.com too. At the Medscape site they don’t say anything about this side effect, priapism, I think it is called, being related to dose or prolonged use.  I would want to know what it is related to, if anything, and what are the early signs of it myself.  I mean, that is a big price to pay for a good nights sleep! Good Luck, keep us informed, Leslie

– Hide quoted text — Show quoted text – Hi saw my Pdoc today. He prescribed trazodone to help with insomnia? Does anyone have knowledge of this drug? He mentioned prolonged erection as a possible side effect. Whats the story….Thanks  I will feel better before starting this to know more…..Fry

Response:

Trazodone is one of the older antidepressants, a tricyclic one I think.

It’s not a tricyclic per se, although it’s often listed with them in the medical reference books for some reason or other.  Not the strongest of the lot, but that’s mitigated somewhat by a few claims I’ve heard from psychiatrists who reckon that they’ve had a lot of success with it where other stuff has failed. Also known as Desyrel.  I have been on it before.  And it was also for

And the rather odd sounding Molipaxin. insomnia.  I got the impression it is prescribed for the side effect of sleepiness more than its anti depressant properties.

This is true; it’s often used as a fairly run of the mill sleeping pill. But I just looked it up at www.medscape.com/druginfo  and you are right, this is a possible side effect and a very serious one it seems.  I never noticed that info before, but maybe I just didn’t pay attention cause I am a woman.

Careful with this one; priapism can also affect women, it’s just not as widely recognised as its male counterpart as it’s, well, less obvious. Don’t know if it has the same nasty effects, though, nor what the incidence of it is in either men or women (low, I think) Chris.

Response:

Hope this helps you out.    trazodone: Pronunciation: TRAZ oh done Brand: Desyrel, Desyrel Dividose What is the most important information I should know about trazodone?  .  Stop taking trazodone and call your doctor immediately if you experience prolonged, painful, or inappropriate erections. This could lead to a serious condition requiring surgery.  .  Use caution when driving, operating machinery, or performing other hazardous activities. Trazodone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.  .  Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.  .  Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking trazodone.  .  Do not stop taking this medication without the approval of your doctor. What is trazodone?  .  Trazodone is an antidepressant medication. It works by changing the actions of chemicals in your brain.  .  Trazodone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.  .  Trazodone may also be used for purposes other than those listed in this medication guide. Who should not take trazodone?  .  You cannot take trazodone if you have had a heart attack in the past 6 weeks. You may also require special monitoring during your therapy if you have any type of heart disease, including a past heart attack, high blood pressure, irregular heartbeats, or chest pain (angina).  .  Trazodone is in the FDA pregnancy category C. This means that it is not known whether trazodone will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.  .  It is not known whether trazodone passes into breast milk. Do not take trazodone without first talking to your doctor if you are breast-feeding a baby. How should I take trazodone?  .  Take trazodone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain the instructions to you.  .  Take each dose with a full glass of water.  .  Take trazodone with a meal or a light snack. Food will increase the amount of the medicine that is absorbed into your body and it will help to decrease dizziness.  .  Do not stop taking trazodone without the approval of your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time. Talk to your doctor before you stop taking this medication.  .  Store trazodone at room temperature away from moisture and heat. What happens if I miss a dose?  .  Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication. What happens if I overdose?  .  Seek emergency medical attention.  .  Symptoms of a trazodone overdose include drowsiness, nausea, vomiting, seizures, an irregular heart beat, difficulty breathing, painful erection, and death. What should I avoid while taking trazodone?  .  Use caution when driving, operating machinery, or performing other hazardous activities. Trazodone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.  .  Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.  .  Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking trazodone. What are the possible side effects of trazodone?  .  If you experience any of the following serious side effects, stop taking trazodone and seek emergency medical attention:      

Back again, still in pain …..

Question:

Tom, I set it up as a drop in channel and sometimes sit in the channel with it running in the background when I’m working online but there is no set time when you will find someone there. It might be an idea to make a date with someone you’d like to visit with:) I sure hear what you say about friends drifting away. It makes me wish that I’d been in a couch potato crowd rather than an athletic one cuz they’ve left me in their dust. I couldn’t x-country 40 metres let alone 40 kilometres now:) love, catherine

– Hide quoted text — Show quoted text – One last thing folks, I have been trying the #chronic_pain IRC channel on starlink and I have not found anyone there despite trying different times of the day. Is there any time in particular people go there? I am in New Zealand and I am not quite sure what the time difference is but I can use /time on the wichita falls server as a reference. Thank you all so much for your help. For me the loneliness is one of the worst parts of chronic pain. I cannot get out like I used to and am not able to do the things my friends still enjoy so they gradually drift away. Reading this ng helps as I feel that I am not as alone. Cheers, Tom

Response:

Hi Debbie, I think Ultram is tramadine hydrochloride (I don’t know the IUPAC name) and is a "new" generation med.

Here is what I found on http://www.rxlist.com.  Ultram’s generic name is Tramadol Hydrochloride…. There is more information on the drug.  I just copied the first page….if you go to the above link and then type in Ultram, you can get all of the information. Robin DESCRIPTION Tramadol hydrochloride is a centrally acting analgesic. The chemical name for tramadol hydrochloride is (

gabitril

Question:

Hi Hopper- Robert found out that Gabritril is a brand name for Tiagabene, which is different than Gabapentin or Neurontin.  His posting pointed to good web site on the drug. Dave

– Hide quoted text — Show quoted text – informed me of this: <Hi, this is my first posting to this NG.  My sister, who is bipolar, is to <be released from the hospital tomarrow.  Apparently the doctors have <prescibed gabitril as a mood stabilizer.  Thank god she’s getting something. <She’s been without a mood stabilizer for more than a year while her illness <has continued destroy her life.  Anyway, does anyone have experience with <this drug in treating bipolar disorder.  I understand that it is one of a <class of drugs that was originally developed for epilepsy.  Any major side <effects (apparently she stopped using a previously prescription because it <made gave her the shakes).  Is it hard to get dialed into the right dosage? <Dave < I am assuming that you are talking about Gabapentin or Neurontin which are the same drug. Neurontin is the brand name. I’ve been on it for over six months and it has done lots of good for me. I’m also assuming that she was taking Lithium which has the side effect of the shakes in some people and you must have a blood test to make sure that you are at the proper serum levels. Neurontin has few side effects and is very forgiving in the dosages. People take as much as 4800 mg/day. It is difficult to OD on. I had ringing in my ears for the first few weeks. It must be taken every 6 to 8 hrs which is a pain. I take it at each meal and bedtime. For many people it is a wonder drug because it has no side effects and works to stabilize your moods. For others it does nothing and is a real disappointment. For me it brought me back from the brink and has made my life worth living again. It is not addictive. She will need to take it for at least a month before all the therapeutic effects are realized. I hope it works well for her. Have her come here and read about others with her illness. It helped me to talk with others of my own kind, so to speak. It might help her. Hopper

Response:

Housewife- Why do you think it will be a nightmare?  Have you or anyone you know been treated with Gabitril?  If so, what were your experiences? Dave

– Hide quoted text — Show quoted text – Gabitril is going to be a nightmare for her.  Why couldn’t they just put her on Lamictal? Hi, this is my first posting to this NG.  My sister, who is bipolar, is to be released from the hospital tomarrow.  Apparently the doctors have prescibed gabitril as a mood stabilizer.  Thank god she’s getting something. She’s been without a mood stabilizer for more than a year while her illness has continued destroy her life.  Anyway, does anyone have experience with this drug in treating bipolar disorder.  I understand that it is one of a class of drugs that was originally developed for epilepsy.  Any major side effects (apparently she stopped using a previously prescription because it made gave her the shakes).  Is it hard to get dialed into the right dosage? Dave

Response:

I found this out earlier from NP Lynda’s post. Retract I, statements past, on medicines unknown by me. Reppoh <It’s not the same thing, the GABA that they have in common in the name <stands for "Gama Amino-Butyric Acid" or something like that. < <-Rob <

< informed me of this: < < <Hi, this is my first posting to this NG.  My sister, who is bipolar, < is to < <be released from the hospital tomarrow.  Apparently the doctors have < <prescibed gabitril as a mood stabilizer.  Thank god she’s getting < something. < <She’s been without a mood stabilizer for more than a year while her < illness < <has continued destroy her life.  Anyway, does anyone have experience < with < <this drug in treating bipolar disorder.  I understand that it is one < of a < <class of drugs that was originally developed for epilepsy.  Any major < side < <effects (apparently she stopped using a previously prescription < because it < <made gave her the shakes).  Is it hard to get dialed into the right < dosage? < <Dave < < < I am assuming that you are talking about Gabapentin or Neurontin which < are the same drug. Neurontin is the brand name. I’ve been on it for < over six months and it has done lots of good for me. I’m also assuming < that she was taking Lithium which has the side effect of the shakes in < some people and you must have a blood test to make sure that you are < at the proper serum levels. < Neurontin has few side effects and is very forgiving in the dosages. < People take as much as 4800 mg/day. It is difficult to OD on. I had < ringing in my ears for the first few weeks. It must be taken every 6 < to 8 hrs which is a pain. I take it at each meal and bedtime. < < For many people it is a wonder drug because it has no side effects and < works to stabilize your moods. For others it does nothing and is a < real disappointment. For me it brought me back from the brink and has < made my life worth living again. It is not addictive. She will need to < take it for at least a month before all the therapeutic effects are < realized. I hope it works well for her. Have her come here and read < about others with her illness. It helped me to talk with others of my < own kind, so to speak. It might help her. < < Hopper <

Response:

I know not of gabitril, never heard of it until now. But I imagine, as with most meds, one patients ‘nightmare’ may be another’s ‘dream come true’. Sara – Hide quoted text — Show quoted text – Gabitril is going to be a nightmare for her.  Why couldn’t they just put her on Lamictal?

Response:

informed me of this: <Hi, this is my first posting to this NG.  My sister, who is bipolar, is to <be released from the hospital tomarrow.  Apparently the doctors have <prescibed gabitril as a mood stabilizer.  Thank god she’s getting something. <She’s been without a mood stabilizer for more than a year while her illness <has continued destroy her life.  Anyway, does anyone have experience with <this drug in treating bipolar disorder.  I understand that it is one of a <class of drugs that was originally developed for epilepsy.  Any major side <effects (apparently she stopped using a previously prescription because it <made gave her the shakes).  Is it hard to get dialed into the right dosage? <Dave < I am assuming that you are talking about Gabapentin or Neurontin which are the same drug. Neurontin is the brand name. I’ve been on it for over six months and it has done lots of good for me. I’m also assuming that she was taking Lithium which has the side effect of the shakes in some people and you must have a blood test to make sure that you are at the proper serum levels. Neurontin has few side effects and is very forgiving in the dosages. People take as much as 4800 mg/day. It is difficult to OD on. I had ringing in my ears for the first few weeks. It must be taken every 6 to 8 hrs which is a pain. I take it at each meal and bedtime. For many people it is a wonder drug because it has no side effects and works to stabilize your moods. For others it does nothing and is a real disappointment. For me it brought me back from the brink and has made my life worth living again. It is not addictive. She will need to take it for at least a month before all the therapeutic effects are realized. I hope it works well for her. Have her come here and read about others with her illness. It helped me to talk with others of my own kind, so to speak. It might help her. Hopper

Response:

Hi, this is my first posting to this NG.  My sister, who is bipolar, is to be released from the hospital tomarrow.  Apparently the doctors have prescibed gabitril as a mood stabilizer.  Thank god she’s getting something. She’s been without a mood stabilizer for more than a year while her illness has continued destroy her life.  Anyway, does anyone have experience with this drug in treating bipolar disorder.  I understand that it is one of a class of drugs that was originally developed for epilepsy.  Any major side effects (apparently she stopped using a previously prescription because it made gave her the shakes).  Is it hard to get dialed into the right dosage? Dave

Response:

Hi, this is my first posting to this NG.  My sister, who is bipolar, is to be released from the hospital tomarrow.  Apparently the doctors have prescibed gabitril as a mood stabilizer.  Thank god she’s getting something. She’s been without a mood stabilizer for more than a year while her illness has continued destroy her life.  Anyway, does anyone have experience with this drug in treating bipolar disorder.

***** I couldn’t find a listing for gabitril.  However, I found a medication called "NEURONTIN" which as a generic (in the US) is called Gabapentin.  I was on it at one time, but cannot remember how it worked.   I understand that it is one of a class of drugs that was originally developed for epilepsy.  Any major side effects (apparently she stopped using a previously prescription because it made gave her the shakes).

***** I am now on a different seizure drug called Lamitical.  I am also on Lithium and shake so bad I can barely write and have dropped many things on the floor.  While I don’t like the "shakes", I like the alternatives, even less.  I am almost always tempted to stop my drugs but know that if I do, I will probably die.   Is it hard to get dialed into the right dosage? ***** I have found that, in my experience, the correct dosages are difficult to guess and may change throughout therapy.  In my case, not every drug works, and even those which do, work for only 3 to 6 months. Good Luck Dave

Response:

Hi Dave and Welcome to the ng. Hi, this is my first posting to this NG.  My sister, who is bipolar, is to be released from the hospital tomarrow.  Apparently the doctors have prescibed gabitril as a mood stabilizer.  Thank god she’s getting something. She’s been without a mood stabilizer for more than a year while her illness has continued destroy her life.  Anyway, does anyone have experience with this drug in treating bipolar disorder.  I understand that it is one of a class of drugs that was originally developed for epilepsy.  Any major side effects (apparently she stopped using a previously prescription because it made gave her the shakes).  Is it hard to get dialed into the right dosage? Dave

I have never taken Gabitril but here is some information about it that was originally posted by James Milton: Most of the following information on Gabitril is obviously related to seizure disorder. However the complete adverse side effect information should be of available through the Gabitril package insert which should be available from your pharmacist. The following information was collected from a variety of Web sources. In 1997 Abbott Laboratories received FDA clearance to market Gabitril as an adjunctive treatment for partial seizures, a form of epilepsy. Gabitril is licensed from Novo-Nordisk A/S of Denmark. Gabitril, which was discovered by Novo Nordisk, is a new anti-epileptic drug with a novel mode of action. The active compound (tiagabine) is a GABA uptake inhibitor. GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter which helps to control the number of impulses between nerve endings in the brain. By stopping GABA from entering nerve endings in the brain, the drug makes it possible to control the abnormal neurotransmitter activity associated with an epileptic seizure. Being the first drug specifically designed as a GABA uptake inhibitor, Gabitril is a new type of antiepileptic drug. GABA (gamma-aminobutyric acid) is an important inhibitor of neurotransmission in the brain and, therefore, a powerful anticonvulsant. Gabitril inhibits the uptake of GABA after a nerve impulse has been transferred across the synapse from one neuron to another. Gabitril ensures that the GABA released at the nerve ending into the synapse space is not reabsorbed, thus preserving the inhibitory effect. This action prevents the abnormally high stimulation that is characteristic of epilepsy. Gabitril is approved for "add-on" therapy for the treatment of partial seizures with or without secondary generalization, in patients aged 12 years and above. Further development is taking place with regard to monotherapy, a first-line treatment for patients with partial seizures. This agent was approved for use in the United States on September 30, 1997 as an adjunctive therapy for adults and children over 12 with partial onset seizures. Possible Mechanism of Action Tiagabine is believed to block reuptake of GABA into the presynaptic terminal by binding to recognition sites of the GABA uptake carrier, leading to accumulation of GABA in the synaptic cleft. Dose Range Suggested adult maintenance dose: 32 to 56 mg/day. Dosage titrations of 4-8 mg/day weekly are suggested by the manufacturer. Comment: Optimal individual maintenance doses will be determined by clinical response; initial doses are lower; pharmacokinetic interactions may affect dosage requirements. Regimen ——- Three to four times per day. Pharmacokinetics Elimination is predominantly hepatic by thiophene ring oxidation and glucuronidation. Half life is approximately 7-9 hours. Some clinically relevant pharmacokinetic drug interactions: Tiagabine may slightly decrease valproate levels, but does not appear to affect levels of other antiepileptic drugs. Tiagabine levels are significantly decreased by hepatic enzyme inducing antiepileptic drugs such as carbamazepine, phenytoin, phenobarbital, and primidone. Valproate significantly decreases binding of tiagabine, leading to increased levels of free tiagabine. The significance of this has not been demonstrated. Adverse Effects Common dose related: tremor, dizziness, nervousness, difficulty concentrating, and sleepiness Comment: All older antiepileptic drugs are potentially teratogenic. Because tiagabine is a recently licensed agent, specific data on risk of teratogenesis is unknown (Pregnancy Category C). Efficacy Tiagabine is approved for use for partial seizures. Gabitril has been approved in more than 15 countries and is currently being marketed in Denmark, Germany, Austria, Switzerland, Ireland, Finland, and France. In addition Abbott Laboratories, who has been granted marketing rights in North America and Mexico, has recently launched Gabitril in the US.

Response:

Gabitril is going to be a nightmare for her.  Why couldn’t they just put her on Lamictal? Hi, this is my first posting to this NG.  My sister, who is bipolar, is to be released from the hospital tomarrow.  Apparently the doctors have prescibed gabitril as a mood stabilizer.  Thank god she’s getting something. She’s been without a mood stabilizer for more than a year while her illness has continued destroy her life.  Anyway, does anyone have experience with this drug in treating bipolar disorder.  I understand that it is one of a class of drugs that was originally developed for epilepsy.  Any major side effects (apparently she stopped using a previously prescription because it made gave her the shakes).  Is it hard to get dialed into the right dosage? Dave

Response:

Pissed

Question:

Steve At some point or another in one of my many quits. It’s nice to see you around again Steve, care to give details :) ) I’m on another quit too and doing good <thus far I might say …

Hi, Jackie!  Good to be seen.  For an answer to your question see meter below.  I haven’t been around much because: a) I’ve been busy; b) I’ve been kinda embarassed about my whiny, childish post when I blew my 7m+ quit in November; c) all of the above. Glad to see you’re doing so well again. All the best, Steve Two months, one week, six days, 18 hours, 33 minutes and 39 seconds. 2467 cigarettes not smoked, saving $367.66. Life saved: 1 week, 1 day, 13 hours, 35 minutes.

Response:

free floating pissed-ness

That is so good.  :-) Edna Pearl  OF

Response:

rick.. I started a better way of living: 10 Hours 46 Minutes 23 Seconds ago. I have NOT smoked 15 cigs., for a savings of $2.36   Extra time to love my children and in a long long time from now grandchildren: 1 Hour 15 Minutes. I will never let it break your heart , I will never let it break me..(everclear)

– Hide quoted text — Show quoted text – Go for it Rik you know we’re all here for you chuck …rant away, and don’t forget the body disposal team, just give the whistle if you need them. (((((((Rik)))))))))) sending lots of positive vibes your way chuck :) padders (

Need Depakote ER info please

Question:

divalproex sodium Pronunciation: dye val PROE ex Brand: Depakote, Depakote ER, Depakote Sprinkles What is the most important information I should know about divalproex sodium?  .  In rare cases, divalproex sodium has caused liver failure, sometimes resulting in death. Children younger than 2 years of age, especially those taking multiple seizure medicines, those with metabolic diseases, those with mental retardation, and those with organic brain disease are at the highest risk of liver failure. Notify your doctor immediately if you develop loss of seizure control, weakness, fatigue, swelling of the face, vomiting, or loss of appetite. These symptoms may be early signs of liver damage.  .  In rare cases, divalproex sodium has also caused severe, even fatal, cases of pancreatitis (inflammation of the pancreas). Some of the cases have progressed rapidly from initial symptoms to death. Cases have been reported soon after starting treatment with divalproex sodium, as well as after several years of use. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, or loss of appetite. These symptoms may be early signs of pancreatitis.  .  Do not stop taking your medication even if you feel better. It is important to continue taking divalproex sodium to prevent your seizures from recurring.  .  Do not crush, chew, or break the capsules or delayed- or extended-release tablets (Depakote, Depakote ER). Swallow them whole.  .  Carry or wear a medical identification tag to let others know that you are taking this medicine in the case of an emergency.  .  Divalproex sodium may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if divalproex sodium is taken with alcohol or any of these medications. Talk to your doctor before taking divalproex sodium in combination with alcohol or any other medicines. What is divalproex sodium?  .  Divalproex sodium affects chemicals in your body that may be involved in causing seizures, migraines, and mania. The exact way that it works is unknown.  .  Divalproex sodium is used to treat various types of seizure disorders, to prevent migraine headaches, and to control mania associated with bipolar disorder.  .  Divalproex sodium may also be used for purposes other than those listed in this medication guide. Who should not take divalproex sodium?  .  Do not take valproic acid if you have liver disease.  .  Divalproex sodium is in the FDA pregnancy category D. This means that it is known to harm an unborn baby. Malformations of the face and head, heart, and nervous system have been reported. Do not take divalproex sodium without first talking to your doctor if you are pregnant.  .  Divalproex sodium passes into breast milk and may affect a nursing infant. Do not take divalproex sodium without first talking to your doctor if you are breast-feeding a baby.  .  Divalproex sodium is not approved for the treatment of migraines in children younger than 16 years of age or for the treatment of mania in children younger than 18 years of age. Extreme caution must be used if valproic acid is used to treat seizures in a child younger than 2 years of age due to the increased risk of liver damage. How should I take divalproex sodium?  .  Take divalproex sodium exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.  .  Take each dose with a full glass of water.  .  Take divalproex sodium with food if it upsets your stomach.  .  Do not crush, chew, or break the capsules or delayed- or extended-release tablets (Depakote, Depakote ER). Swallow them whole.  .  The sprinkle capsules can either be swallowed whole or opened and sprinkled onto some soft food such as applesauce or pudding.  .  Your doctor may want you to have blood tests during your therapy. It is important for your doctor to know how much medication is in your blood and how well your liver is working.  .  Carry or wear a medical identification tag to let others know that you are taking this medicine in the case of an emergency.  .  Do not stop taking your medication even if you feel better. It is important to continue taking divalproex sodium to prevent your seizures from recurring.  .  Store divalproex sodium at room temperature away from moisture and heat. What happens if I miss a dose?  .  Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication. What happens if I overdose?  .  Seek emergency medical attention.  .  Symptoms of a divalproex sodium overdose include unconsciousness, sleepiness or drowsiness, faint or no heartbeat, decreased breathing, or stopped breathing. What should I avoid while taking divalproex sodium?  .  Divalproex sodium may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if divalproex sodium is taken with alcohol or any of these medications. Talk to your doctor before taking divalproex sodium in combination with alcohol or any other medicines.  .  Use caution when driving, operating machinery, or performing other hazardous activities. Divalproex sodium may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. What are the possible side effects of divalproex sodium?  .  In rare cases, divalproex sodium has caused liver failure, sometimes resulting in death. Children younger than 2 years of age, especially those taking multiple seizure medicines, those with metabolic diseases, those with mental retardation, and those with organic brain disease are at the highest risk of liver failure. Notify your doctor immediately if you develop loss of seizure control, weakness, fatigue, swelling of the face, vomiting, or loss of appetite. These symptoms may be early signs of liver damage.  .  In rare cases, divalproex sodium has also caused severe, even fatal, cases of pancreatitis (inflammation of the pancreas). Some of the cases have progressed rapidly from initial symptoms to death. Cases have been reported soon after starting treatment with divalproex sodium, as well as after several years of use. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, or loss of appetite. These symptoms may be early signs of pancreatitis.  .  If you experience any of the following serious side effects, stop taking divalproex sodium and seek emergency medical attention:      

Philip, Margrove, anybody help

Question:

How do you know Remeron caused the rash? Nobody can say for sure. But the first time the rash appeared coincided with the use of Remeron. Since then it has appeared with every med. she took caused the same rash. So we thought maybe it’s the fillers and Diana Perhaps Diana has a chronic skin condition unrelated to the meds she has taken. Indeed. But it seems at least remarkable that the rash disappears when she’s not taking any meds and reappears as soon as she starts taking one, whichever…

I haven’t been following this, and I don’t know much about allergic reactions to the various chemicals in meds, but it seems to me there can only be two valid explanations for this. 1) there is a common allergin in all the meds she has tried. Possible. 2) It is a "nervous" reactions to taking medications. This is quite possible. A allergy specialist may be able to sort it out. Ian

Response:

Philip, No it is not the time of the year, I love this time when the evenings are long.

I see….I like long evenings too but my favourite season remains summer when one can go out without a coat even in H olland…. Today was the day that my mother died so I had a hell of a week.

I can relate….. I am sorry about that. Also whe had to go out of the house and than I need more valium. Maybe you know the pleace, Steenwijk, Emmeloord,

Yep. I have been to Steenwijk and I seem to remember Emmeloord as well. How much Valium do you take on such a day and did it go well? Love Diana.

Philip – Hide quoted text — Show quoted text – The rash on my body wors than before. Oh dear…..you get it coming and going, don’t you? I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest. Doesn’t sound good at all. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test. What hospital, Diana? I am appalled, indeed almost speechless, at the Groningen university clinic dermatologist…. you should think about suing her. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time. This is a bad time for many people with PAD what with the days getting shorter and darker and the ominous Holiday Season drawing near…. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will. Yes, the fillers…. we thought that all along….I am beinning to believe that there must have been something with the Remeron that caused it….I didn’t believe that at first… Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes. Poor soul…..*&^$%# !! To the AMC, Diana? I am all for it and always have been. I am very disappointed in the Groningen hospital. You have every reason to be *very angry* now, IMO. Love Diana. Philip

Response:

Philip, She don’t say to me that she was a real doc, that is maybe why she would not answer my questions. I have try the find out if i have take some other soap or what i am eating, but there is nothing that i can find. It is all the same as 2 years ago.

I don’t agree. You have learned a lot, for example: that it *is* possible to have *no* anxiety. This was when you first were on the Remeron and felt like you had gotten a *new life* and you flew to Ireland and had a great vacation and lots more of great stuff. So it is *proven* that you can live without anxiety. Now you have bad luck with this bitch doctor in Groningen but let’s wait for the results of the bloodwork and if that isn;t satisfying I think you should indeed go back to the AMC. I feel the solution is *around the corner* and someday soon you will find it. You know how it work in a university clinic, they don’t say nothing. This morning i went to a other hospital for a blood test and i hope that they will find something. This is something that can’t go on, I DON’T want this NO more.

Of course you don’t want this anymore, it’s quite terrible. BUT not wanting it anymore means trying *everything* to change it. I simply do NOT believe that you will be the only human being in the world who can’t make progress with anxiety, especialluy as it has been proven that you can. (Grammar Problem: I suddenly forget whether it is *proven* or *proved*…anybody please? ;) ) I am tired of all this, in a other message you ask me how it went to Emmeloord and Steenwijk, I don’t know I was so stoned from the valium so I don’t remember very much of the ride. How much I take?? to much.

How much is that? I told you all that I will try to go to Amsterdam AMC, but don’t forget it is for me very far

I know but if necessary you can do it. I wonder if you have relatives or good friends in Amsterdam where you could stay for a bit if necessary. After all you are from Amsterdam (as am I)…. or they should admit you as an inpatient in order to do every test under the sun. Did you read Margrove’s and Chip’s posts? If not I have them filed away and can forward them to you. And it will take a lot of me, but maybe that my Pdoc can help me when he is back. He can do more than I can.

Hm…you can do *everything*, actually it’s amazing how strong you are. The pdoc can help you help yourself. In the meantime why not find a CB-therapist? That’s *active work* which is most rewarding as you can literally make yourself progress….. and there *is* a CBT-therapist in your very street….(me havem good memory, benzobrain or no benzobrain). If you can go to Groningen or even Amsterdam you can also go to the closest CBT practice – they may have one in Meppel too. The great thing about CBT is that you can actually *do* something for yourself, *work* on it which is effective and a boost to your self esteem, I promise you that. Love Diana.

Philip – Hide quoted text — Show quoted text – The peculiar thing is that Diana (hi, Diana, we’re talking *about* you! Sshtt! *We* are talking *about* you ;) )) had been on several AD’s and benzos for years without any skin problem. Then she was goven remeron which was the first med that actually worked for her and gave her her life back and then she had to stop taking it because it caused this rash. So far so good. But from then on every med How do you know Remeron caused the rash? Nobody can say for sure. But the first time the rash appeared coincided with the use of Remeron. Since then it has appeared with every med. she took caused the same rash. So we thought maybe it’s the fillers and Diana Perhaps Diana has a chronic skin condition unrelated to the meds she has taken. Indeed. But it seems at least remarkable that the rash disappears when she’s not taking any meds and reappears as soon as she starts taking one, whichever… tried liquid Prozac (is that right, Diana or is *benzobrain* here confusing his meds?) with *no* fillers and still got the rash. Also now on Valium. What in the That supports the notion that her rash is not caused by her meds or by their fillers. You may be right but it still seems med related because it only appears when she takes a med. Even if this were coincidental, what could it be? world can have caused this? It seems like *something* in the Remeron. But what? I would not assume (based on what I know of the facts) that her rash is caused by Remeron. Or by any of the meds she has taken. You may very well be right. But what *can* it be? And how? And why? And how to go on? Now there was this dermatologist at Groningen university clinic who diagnosed her with *rosacea* but it’s not in her face, but on her chest….3 GP’s say the diagnosis is incorrect. Even if it was correct the wrong med was prescribed…. To the best of my knowledge, rosacea  occurs *only* on the face. Perhaps Diana has two types of rashes: Rosacea on her face, and another type of rash on her chest. I’ve seen patients with 3 or 4 different types of rashes on various parts of their body all at the same time. Hm….this warrants more research… What a mess…. there should be a clear step by step plan for a *complete* examination of Diana’s blood and someone should look more closely into the Remeron connection. I’ve never heard of something like this before, have you, Margrove? Chip? I wonder if Diana saw a med student or resident at the University she went to. And not a full blown dermatolgist. Dianaaaaaaaaa! Was the doc you saw een *assistent* of een echte al heel lang afgestudeerde huidarts? I think it’s a good idea if Diana went to the AMC, the Amsyterdam University clinic. But wouldn’t it be best if she could write down *exactly* what to ask and No. She should say she’s depressed, anxious, and has a rash and wants diagnoses and treatment for them. Let the doctors think of the appropriate questions to ask Diana. Of course. But why not go both ways? what to have done? This has to be treated and fast and good. She shouldn’t have to suffer like this for so long at the hands of all sorts of incompetent doctors. Help. Philip That Amsterdam University Clinic sounds like a good bet. She should see a generalist (i.e. GP, Family Practioner, or Internest) first for evaluation, and he can make appropriate referrals for psych and derm if necessary. Chip On behalf of Diana and the Dutch people in general: thank you for your advice which is certainly illuminating IMO. Philip Before you buy.

Response:

Philip, She don’t say to me that she was a real doc, that is maybe why she would not answer my questions. I have try the find out if i have take some other soap or what i am eating, but there is nothing that i can find. It is all the same as 2 years ago. You know how it work in a university clinic, they don’t say nothing. This morning i went to a other hospital for a blood test and i hope that they will find something. This is something that can’t go on, I DON’T want this NO more. I am tired of all this, in a other message you ask me how it went to Emmeloord and Steenwijk, I don’t know I was so stoned from the valium so I don’t remember very much of the ride. How much I take?? to much. I told you all that I will try to go to Amsterdam AMC, but don’t forget it is for me very far And it will take a lot of me, but maybe that my Pdoc can help me when he is back. He can do more than I can. Love Diana. – Hide quoted text — Show quoted text – The peculiar thing is that Diana (hi, Diana, we’re talking *about* you! Sshtt! *We* are talking *about* you ;) )) had been on several AD’s and benzos for years without any skin problem. Then she was goven remeron which was the first med that actually worked for her and gave her her life back and then she had to stop taking it because it caused this rash. So far so good. But from then on every med How do you know Remeron caused the rash? Nobody can say for sure. But the first time the rash appeared coincided with the use of Remeron. Since then it has appeared with every med. she took caused the same rash. So we thought maybe it’s the fillers and Diana Perhaps Diana has a chronic skin condition unrelated to the meds she has taken. Indeed. But it seems at least remarkable that the rash disappears when she’s not taking any meds and reappears as soon as she starts taking one, whichever… tried liquid Prozac (is that right, Diana or is *benzobrain* here confusing his meds?) with *no* fillers and still got the rash. Also now on Valium. What in the That supports the notion that her rash is not caused by her meds or by their fillers. You may be right but it still seems med related because it only appears when she takes a med. Even if this were coincidental, what could it be? world can have caused this? It seems like *something* in the Remeron. But what? I would not assume (based on what I know of the facts) that her rash is caused by Remeron. Or by any of the meds she has taken. You may very well be right. But what *can* it be? And how? And why? And how to go on? Now there was this dermatologist at Groningen university clinic who diagnosed her with *rosacea* but it’s not in her face, but on her chest….3 GP’s say the diagnosis is incorrect. Even if it was correct the wrong med was prescribed…. To the best of my knowledge, rosacea  occurs *only* on the face. Perhaps Diana has two types of rashes: Rosacea on her face, and another type of rash on her chest. I’ve seen patients with 3 or 4 different types of rashes on various parts of their body all at the same time. Hm….this warrants more research… What a mess…. there should be a clear step by step plan for a *complete* examination of Diana’s blood and someone should look more closely into the Remeron connection. I’ve never heard of something like this before, have you, Margrove? Chip? I wonder if Diana saw a med student or resident at the University she went to. And not a full blown dermatolgist. Dianaaaaaaaaa! Was the doc you saw een *assistent* of een echte al heel lang afgestudeerde huidarts? I think it’s a good idea if Diana went to the AMC, the Amsyterdam University clinic. But wouldn’t it be best if she could write down *exactly* what to ask and No. She should say she’s depressed, anxious, and has a rash and wants diagnoses and treatment for them. Let the doctors think of the appropriate questions to ask Diana. Of course. But why not go both ways? what to have done? This has to be treated and fast and good. She shouldn’t have to suffer like this for so long at the hands of all sorts of

incompetent doctors. – Hide quoted text — Show quoted text – Help. Philip That Amsterdam University Clinic sounds like a good bet. She should see a generalist (i.e. GP, Family Practioner, or Internest) first for evaluation, and he can make appropriate referrals for psych and derm if necessary. Chip On behalf of Diana and the Dutch people in general: thank you for your advice which is certainly illuminating IMO. Philip Before you buy.

Response:

Philip, No it is not the time of the year, I love this time when the evenings are long. Today was the day that my mother died so I had a hell of a week. Also whe had to go out of the house and than I need more valium. Maybe you know the pleace, Steenwijk, Emmeloord, Love Diana. – Hide quoted text — Show quoted text – The rash on my body wors than before. Oh dear…..you get it coming and going, don’t you? I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest. Doesn’t sound good at all. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test. What hospital, Diana? I am appalled, indeed almost speechless, at the Groningen university clinic dermatologist…. you should think about suing her. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time. This is a bad time for many people with PAD what with the days getting shorter and darker and the ominous Holiday Season drawing near…. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will. Yes, the fillers…. we thought that all along….I am beinning to believe that there must have been something with the Remeron that caused it….I didn’t believe that at first… Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes. Poor soul…..*&^$%# !! To the AMC, Diana? I am all for it and always have been. I am very disappointed in the Groningen hospital. You have every reason to be *very angry* now, IMO. Love Diana. Philip

Response:

Topical metronidazole, in either 0.75% gel twice daily or 1% cream once daily, is the topical treatment of choice for Rosacea. Chip I’ll have you talk to my wife she’s a dermotologist and insists it isn’t except in textbooks LM

Anyway, the subject at hand isn’t Rosacea at all as it seems so this little dispute is of little consequence. P.

Response:

The peculiar thing is that Diana (hi, Diana, we’re talking *about* you! Sshtt! *We* are talking *about* you ;) )) had been on several AD’s and benzos for years without any skin problem. Then she was goven remeron which was the first med that actually worked for her and gave her her life back and then she had to stop taking it because it caused this rash. So far so good. But from then on every med How do you know Remeron caused the rash?

Nobody can say for sure. But the first time the rash appeared coincided with the use of Remeron. Since then it has appeared with every med. she took caused the same rash. So we thought maybe it’s the fillers and Diana Perhaps Diana has a chronic skin condition unrelated to the meds she has taken.

Indeed. But it seems at least remarkable that the rash disappears when she’s not taking any meds and reappears as soon as she starts taking one, whichever… tried liquid Prozac (is that right, Diana or is *benzobrain* here confusing his meds?) with *no* fillers and still got the rash. Also now on Valium. What in the That supports the notion that her rash is not caused by her meds or by their fillers.

You may be right but it still seems med related because it only appears when she takes a med. Even if this were coincidental, what could it be? world can have caused this? It seems like *something* in the Remeron. But what? I would not assume (based on what I know of the facts) that her rash is caused by Remeron. Or by any of the meds she has taken.

You may very well be right. But what *can* it be? And how? And why? And how to go on? Now there was this dermatologist at Groningen university clinic who diagnosed her with *rosacea* but it’s not in her face, but on her chest….3 GP’s say the diagnosis is incorrect. Even if it was correct the wrong med was prescribed…. To the best of my knowledge, rosacea  occurs *only* on the face. Perhaps Diana has two types of rashes: Rosacea on her face, and another type of rash on her chest. I’ve seen patients with 3 or 4 different types of rashes on various parts of their body all at the same time.

Hm….this warrants more research… What a mess…. there should be a clear step by step plan for a *complete* examination of Diana’s blood and someone should look more closely into the Remeron connection. I’ve never heard of something like this before, have you, Margrove? Chip? I wonder if Diana saw a med student or resident at the University she went to. And not a full blown dermatolgist.

Dianaaaaaaaaa! Was the doc you saw een *assistent* of een echte al heel lang afgestudeerde huidarts? I think it’s a good idea if Diana went to the AMC, the Amsyterdam University clinic. But wouldn’t it be best if she could write down *exactly* what to ask and No. She should say she’s depressed, anxious, and has a rash and wants diagnoses and treatment for them. Let the doctors think of the appropriate questions to ask Diana.

Of course. But why not go both ways? what to have done? This has to be treated and fast and good. She shouldn’t have to suffer like this for so long at the hands of all sorts of incompetent doctors. Help. Philip That Amsterdam University Clinic sounds like a good bet. She should see a generalist (i.e. GP, Family Practioner, or Internest) first for evaluation, and he can make appropriate referrals for psych and derm if necessary. Chip

On behalf of Diana and the Dutch people in general: thank you for your advice which is certainly illuminating IMO. Philip – Hide quoted text — Show quoted text – Before you buy.

Response:

The peculiar thing is that Diana (hi, Diana, we’re talking *about* you! Sshtt! *We* are talking *about* you ;) )) had been on several AD’s and benzos for years without any skin problem. Then she was goven remeron which was the first med that actually worked for her and gave her her life back and then she had to stop taking it because it caused this rash. So far so good. But from then on every med How do you know Remeron caused the rash? Nobody can say for sure. But the first time the rash appeared coincided with the use of Remeron. Since then it has appeared with every med.

Did the rash disappear when she stopped the Remeron? One would have to look very closely at the temporal relationship between the start of a med and the onset of a rash. As well as stopping the med with disappearance of the rash. Are these observations made by a physician? she took caused the same rash. So we thought maybe it’s the fillers and Diana Perhaps Diana has a chronic skin condition unrelated to the meds she has taken. Indeed. But it seems at least remarkable that the rash disappears when she’s not taking any meds and reappears as soon as she starts taking one, whichever…

Has a physician observed this? tried liquid Prozac (is that right, Diana or is *benzobrain* here confusing his meds?) with *no* fillers and still got the rash. Also now on Valium. What in the That supports the notion that her rash is not caused by her meds or by their fillers. You may be right but it still seems med related because it only appears when she takes a med. Even if this were coincidental, what could it be?

It could be alot of different kinds of rashes. However, a good rule of thumb is that common rashes tend to occur more commonly than rare ones. And she may have a common skin rash completely unrelated to any meds she’s taking. – Hide quoted text — Show quoted text – world can have caused this? It seems like *something* in the Remeron. But what? I would not assume (based on what I know of the facts) that her rash is caused by Remeron. Or by any of the meds she has taken. You may very well be right. But what *can* it be? And how? And why? And how to go on? Now there was this dermatologist at Groningen university clinic who diagnosed her with *rosacea* but it’s not in her face, but on her chest….3 GP’s say the diagnosis is incorrect. Even if it was correct the wrong med was prescribed…. To the best of my knowledge, rosacea  occurs *only* on the face. Perhaps Diana has two types of rashes: Rosacea on her face, and another type of rash on her chest. I’ve seen patients with 3 or 4 different types of rashes on various parts of their body all at the same time. Hm….this warrants more research…

And Diana should report her symptoms and let the doctors do the reasearch for the answers. What a mess…. there should be a clear step by step plan for a *complete* examination of Diana’s blood and someone should look more closely into the Remeron connection. I’ve never heard of something like this before, have you, Margrove? Chip? I wonder if Diana saw a med student or resident at the University she went to. And not a full blown dermatolgist. Dianaaaaaaaaa! Was the doc you saw een *assistent* of een echte al heel lang afgestudeerde huidarts?

Ask Diana if she accidently saw the janitor instead of a doctor. ;) I think it’s a good idea if Diana went to the AMC, the Amsyterdam University clinic. But wouldn’t it be best if she could write down *exactly* what to ask and No. She should say she’s depressed, anxious, and has a rash and wants diagnoses and treatment for them. Let the doctors think of the appropriate questions to ask Diana. Of course. But why not go both ways?

If the time with the doctor is limited, I would let the doctor take the lead in asking questions he thinks are important. It will be hard for the doctor to answer Diana’s questions before he has some idea of what her problems are. – Hide quoted text — Show quoted text – what to have done? This has to be treated and fast and good. She shouldn’t have to suffer like this for so long at the hands of all sorts of incompetent doctors. Help. Philip That Amsterdam University Clinic sounds like a good bet. She should see a generalist (i.e. GP, Family Practioner, or Internest) first for evaluation, and he can make appropriate referrals for psych and derm if necessary. Chip On behalf of Diana and the Dutch people in general: thank you for your advice which is certainly illuminating IMO. Philip

Myself and all the people of the USA are happy to do whatever we can for Diana and the rest of the Dutch people. Chip Before you buy.

Before you buy.

Response:

Metronidazole

well in that case if this is rosacea topical antifungals can make it worse in some cases and cause some eruptive dermatosis-so Diana may just be highly allergenic and skin sensitive-the tetracycline orally may help in a few days but this had best be looked at by a dermo-one can also absorb this stuff through the skin and its effects seen elsewhere if hypersensitive to it LM

Response:

Margrove asked:

another thought-years ago I had a client who had developed a significant urinary tract infection she went through a culture and sensitivity or her urine and it was a microbe that was only killed by pennicilin-It was determined that the only form that had accesibility to the area of her urinary tract this was breeding in was carbenicillin-she was highly allergic to penicillins and other meds with similar antimicrobial effect were useless-so her doc gave her geocillin and benadryl and she got better with no allergic reactions-if Dianna’s psychiatric condition deems it necessary she could go this route as well provided it’s risk vrs benefit ratio is intact-It is hard to believe that of all the available meds in the antidepressant arena some of which have weak antihistamic properties by themselves will cause an allergic reaction. The other meds may not deliver as much relief as is wanted but they may help. the available polypharmocological possibilities are huge including mood stabilizers reversinle and irreversible maoi’s nueroleptics and not the very least cbt-Paying such focus on drug cures is in some cases a waste of time if the patient is intolerant of all of them for whatever reason. Which I find hard to believe. If no other organic reason is found using even non scientific allergenic testing like rast blood tests with diluted ad meds to see if antigens are present-then one must conclude that meds are not an option. But this has not been exhausted as of yet as far as I can see. Professional intervention from someone who is willing to put the time in and use a medicaly viable bases for their conclusions is mandatory and I do hope is obtained. If not in the Netherlands then somewhere else that is accesible LM

Response:

Metronidazole well in that case if this is rosacea topical antifungals can make it worse in

Topical metronidazole, in either 0.75% gel twice daily or 1% cream once daily, is the topical treatment of choice for Rosacea. Chip some cases and cause some eruptive dermatosis-so Diana may just be highly allergenic and skin sensitive-the tetracycline orally may help in a few days but this had best be looked at by a dermo-one can also absorb this stuff through the skin and its effects seen elsewhere if hypersensitive to it LM

Before you buy.

Response:

This is all I can offer you because I’m not a doctor.  I hope you blast them all at that hospital!!! Love, Di

– Hide quoted text — Show quoted text – The rash on my body wors than before. I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will. Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes. Love Diana.

Response:

- Hide quoted text — Show quoted text – The rash on my body wors than before. I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will. Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes.

Dear Diana, I am so sorry this is happening to you. I want to wish you much luck at the hospital tomorrow, hopefully they will have some answers for you. Hang in there, this is going to be taken care of, I am sure of it. Jackie

Response:

Topical metronidazole, in either 0.75% gel twice daily or 1% cream once daily, is the topical treatment of choice for Rosacea. Chip

I’ll have you talk to my wife she’s a dermotologist and insists it isn’t except in textbooks LM

Response:

Hi, Diana, Sorry to hear about your rash.  Besure to follow up on the blood test tomorrow – call your doctor afterwards and see what he says.  if he offers nothing TELL him you WANT to see a determalogist TODAY.  they have played around too long with you you need to be very assertive and get some results. Please keep us posted.   ((((((DIANA))))))  - thinking of you! smiles, elise

– Hide quoted text — Show quoted text – The rash on my body wors than before. I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will. Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes. Love Diana.

Response:

Metronidazole well in that case if this is rosacea topical antifungals can make it worse in some cases and cause some eruptive dermatosis-so Diana may just be highly allergenic and skin sensitive-the tetracycline orally may help in a few days but this had best be looked at by a dermo-one can also absorb this stuff through the skin and its effects seen elsewhere if hypersensitive to it LM

The peculiar thing is that Diana (hi, Diana, we’re talking *about* you! Sshtt! *We* are talking *about* you ;) )) had been on several AD’s and benzos for years without any skin problem. Then she was goven remeron which was the first med that actually worked for her and gave her her life back and then she had to stop taking it because it caused this rash. So far so good. But from then on every med she took caused the same rash. So we thought maybe it’s the fillers and Diana tried liquid Prozac (is that right, Diana or is *benzobrain* here confusing his meds?) with *no* fillers and still got the rash. Also now on Valium. What in the world can have caused this? It seems like *something* in the Remeron. But what? And how? And why? And how to go on? Now there was this dermatologist at Groningen university clinic who diagnosed her with *rosacea* but it’s not in her face, but on her chest….3 GP’s say the diagnosis is incorrect. Even if it was correct the wrong med was prescribed…. What a mess…. there should be a clear step by step plan for a *complete* examination of Diana’s blood and someone should look more closely into the Remeron connection. I’ve never heard of something like this before, have you, Margrove? Chip? I think it’s a good idea if Diana went to the AMC, the Amsyterdam University clinic. But wouldn’t it be best if she could write down *exactly* what to ask and what to have done? This has to be treated and fast and good. She shouldn’t have to suffer like this for so long at the hands of all sorts of incompetent doctors. Help. Philip

Response:

The rash on my body wors than before.

Oh dear…..you get it coming and going, don’t you? I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest.

Doesn’t sound good at all. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test.

What hospital, Diana? I am appalled, indeed almost speechless, at the Groningen university clinic dermatologist…. you should think about suing her. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time.

This is a bad time for many people with PAD what with the days getting shorter and darker and the ominous Holiday Season drawing near…. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will.

Yes, the fillers…. we thought that all along….I am beinning to believe that there must have been something with the Remeron that caused it….I didn’t believe that at first… Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes.

Poor soul…..*&^$%# !! To the AMC, Diana? I am all for it and always have been. I am very disappointed in the Groningen hospital. You have every reason to be *very angry* now, IMO. Love Diana.

Philip

Response:

rosacea*

rarely affects large areas of the body-it can but usually doesn’t-if other docs see this inflamation and conclude it isn’t rosacea then why does one claim it is? If one is allergic to remeron or whatever fillers are in it or one has a dermotological sensitivity to one class of drugs they wouldn’t to all-unless they have a very serious problem like a type 1 ige reaction or a type 2 cytotoxic one or type 3 complex reactions-the only way to determine this is by examination and testing-all I can say is in 25 years I have had clients who are allergic to one specific med or class but not to all according to my wife oral meds are used for the best treatment of rosacea and one is the antibiotic tetracycline with oral flagyl (her antifungal cream in oral form) topicaly or oraly administered retinoids for some forms and there are two new meds on the market here which I am not familiar with-my rotation in dermo was brief and rosacea was only covered in text not in person and back then the treatment was wrong anyway. I have not seen anything like this so a much more thorough exam by a dermo and or an allergist is called for with lots of blood work to see if it is something much more sinister -bottom line if drugs are not feasible then rigorous therapy is but there are so many meds that I cannot believe one cannotbe found that helps even if it is not revelatory-remeron is a good drug for depression-if it worked then similar mechanisms of action can be replecated with others-or treatment can resume with it once the etiology of her rash is determined and that should be the primary goal LM

Response:

Topical metronidazole, in either 0.75% gel twice daily or 1% cream once daily, is the topical treatment of choice for Rosacea. Chip I’ll have you talk to my wife she’s a dermotologist and insists it isn’t except in textbooks LM

Dermatol Clin 2000 Jan;18(1):63-71, viii Acne and rosacea. New and emerging therapies. Thiboutot DM  Section of Dermatology, Pennsylvania State University, College The goal of this article is to highlight recent developments in the treatment of acne and rosacea. An update on the use of isotretinoin, minocycline, topical retinoids, and hormones in the treatment of acne are presented. Highlights of research findings that may lead to future acne therapies are discussed. **New in the management of rosacea are studies demonstrating the efficacy of 1% topical metronidazole in the treatment of rosacea, reports on the successful maintenance of remissions of rosacea with 0.75% metronidazole gel**, and data regarding the controversial association of rosacea with Helicobacter pylori infection. Before you buy.

Response:

– Hide quoted text — Show quoted text – Metronidazole well in that case if this is rosacea topical antifungals can make it worse in some cases and cause some eruptive dermatosis-so Diana may just be highly allergenic and skin sensitive-the tetracycline orally may help in a few days but this had best be looked at by a dermo-one can also absorb this stuff through the skin and its effects seen elsewhere if hypersensitive to it LM The peculiar thing is that Diana (hi, Diana, we’re talking *about* you! Sshtt! *We* are talking *about* you ;) )) had been on several AD’s and benzos for years without any skin problem. Then she was goven remeron which was the first med that actually worked for her and gave her her life back and then she had to stop taking it because it caused this rash. So far so good. But from then on every med

How do you know Remeron caused the rash? she took caused the same rash. So we thought maybe it’s the fillers and Diana

Perhaps Diana has a chronic skin condition unrelated to the meds she has taken. tried liquid Prozac (is that right, Diana or is *benzobrain* here confusing his meds?) with *no* fillers and still got the rash. Also now on Valium. What in the

That supports the notion that her rash is not caused by her meds or by their fillers. world can have caused this? It seems like *something* in the Remeron. But what?

I would not assume (based on what I know of the facts) that her rash is caused by Remeron. Or by any of the meds she has taken. And how? And why? And how to go on? Now there was this dermatologist at Groningen university clinic who diagnosed her with *rosacea* but it’s not in her face, but on her chest….3 GP’s say the diagnosis is incorrect. Even if it was correct the wrong med was prescribed….

To the best of my knowledge, rosacea  occurs *only* on the face. Perhaps Diana has two types of rashes: Rosacea on her face, and another type of rash on her chest. I’ve seen patients with 3 or 4 different types of rashes on various parts of their body all at the same time. What a mess…. there should be a clear step by step plan for a *complete* examination of Diana’s blood and someone should look more closely into the Remeron connection. I’ve never heard of something like this before, have you, Margrove? Chip?

I wonder if Diana saw a med student or resident at the University she went to. And not a full blown dermatolgist. I think it’s a good idea if Diana went to the AMC, the Amsyterdam University clinic. But wouldn’t it be best if she could write down *exactly* what to ask and

No. She should say she’s depressed, anxious, and has a rash and wants diagnoses and treatment for them. Let the doctors think of the appropriate questions to ask Diana. what to have done? This has to be treated and fast and good. She shouldn’t have to suffer like this for so long at the hands of all sorts of incompetent doctors. Help. Philip

That Amsterdam University Clinic sounds like a good bet. She should see a generalist (i.e. GP, Family Practioner, or Internest) first for evaluation, and he can make appropriate referrals for psych and derm if necessary. Chip Before you buy.

Response:

The rash on my body wors than before. I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will. Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes. Love Diana.

Response:

Elyzol 1%

I don’t know what this is-what is the chemical name on the tube??? Get over to a dermotologist or an allergist for them to see what kind of rash this is-there are many quite serious autoimmune problems this could be-most serious cases of rosacea cannot be treated topicaly especialy if the area effected is large-which is why I made mention of topical preperations of weak antibiotics as not used unless the condition is basicaly on your nose and mild-If it is not rosacea you may need some oral steroids and some oral antihistamines-If you go to a doc and they are unsure what you have if they can log onto the web they can take a digital picture and e-mail it to any one of a dozen very qualified dermotology departments at major teaching hospitals in the U.S. or Europe-this has gone on so long it is a crime-If the sores are oozing let them it is suppossed to as the tissue underneath is trying to stay sterile and heal-think of it as burns and keep the dressings clean and changed often-don’t use things like vaseline or aloe until you get an accurate diagnosis. Please do this now and don’t wait-It may be something just annoying or it may be serious-let me know what the chemical name of the cream or lotion is I cannot find it on my database of cross referenced drugs. LM

Response:

– Hide quoted text — Show quoted text – The rash on my body wors than before. I was in the university clinic and she give me Elyzol 1%, but that is now the trouble. This morning I was to my GP and they are there with 3GP’s. I have show them wat this med; do to me. it eat’s my skin away. the liquid flow out of my skin, and the most where I have it ,is on my chest. My own GP ask the other 2 if they want to look at it, and both they say she in the university has it wrong. This can’t be Rosacea, so I go tomorrow to a other hopital for a blood test. He give me now Tetracycline caps 250mg because it is now inflamed, I have to take that for 14 day’s and than he will see it again, if I would not have trouble with any side effect’s than I have to come sooner. Not only my own GP was angry but also the other 2GP’s. I have told them that I had to take the last days more valium than I normel do because this is not one of my best time. They are also the meaning that it has to do something with the fillers in the med; that I have used the last 2 years. so if thid bring me nothing I wil ask my Pdoc when I see him(jan9) what I can do and if he don’t know I will. Than I go to the west of the Netherlands(Amsterdam, to my own people) and I will ask them If they want to help me. If you could see me now how my chest look it is dirthy. I need to use bandage for my clothes. Love Diana.

In dutch,sorry Diana, Willem heeft een tijd geleden een hele vreemde uitslag gehad De huidartsen hier wisten absoluut geen raad met het hele geval. Gelukkig hebben ze hem doorgestuurd naar Nijmegen,naar een zekere dokter Steensel. Deze zag bijna meteen wat het was. Een ziekte die bijna niet voorkomt,de ziekte van yesner. Hij is nu genezen. Wat ik bedoel is niet dat jij dat hebt,maar dat je een heeeeeeeeeeele goede huidarts moet zoeken. Misschien moet je inderdaad overwegen zo snel mogelijk naar Amsterdam te gaan. Zet maar druk op je huisarts. Het is helemaal nergens voor nodig dat alles zo akelig moet gaan voor jou!!!! Dag Lieverd laat van je horen  Anna – Hide quoted text — Show quoted text –

Response:

Margrove asked: I don’t know what this is-what is the chemical name on the tube???

From what I can tell, and it was hard because everything is written in Dutch, Metronidazole is the generic name for Elyzol. This has alot of info: http://www.rxlist.com/cgi/generic/metronid.htm                Metronidazole Categories: Abscess, Abdominal; Abscess, Hepatic; Abscess, Lung; Abscess, Pulmonary; Amebiasis; Endocarditis; Endometritis; Helicobacter Pylori; Infection, Bone; Infection, Gynecologic; Infection, Intra-abdominal; Infection, Joint; Infection, Local; Infection, Respiratory Tract; Infection, Skin; Meningitis; Peritonitis; Pneumonia; Prophylaxis, Perioperative; Septicemia; Sexually Transmitted Diseases; Trichomoniasis; Vaginosis, Bacterial; Pregnancy Category B; FDA Approved 1980 Feb; WHO Formulary; Orphan Drugs FDA Drug Class: Antibacterials, Miscellaneous; Antidiarrheals; Antiprotozoals; Dermatologics; Disorders, Acid/Peptic; Gastrointestinal, Miscellaneous; Tetracyclines Brand Names: Acromona; Amibazol; Amiyodazol; Anaerobex; Anerobia; Apo-Metronidazole; Arcazol; Arilin; Ariline; Asiazole; Asuzol; Camezol; Clont; Fladex; Flagenase; Flagyl; Flagyl 375; Flasinyl; Fossyol; Frotin; Fulikan; Fuzuzin; Klion; Medai; Melis; Metarsal; Metizol; Metro IV; Metrocream; Metrogel; Metrogyl; Metrolag; Metrolex; Metromidol; Metronidazole IV; Metronidazol McKesson; Metroxyn; Metroxyn 500; Metrozin; Metrozine; Metrozole; Metryl; Nalox; Nida; Nitrozol; Noritate; Norstene; Novazole; Novonidazole; Protostat; Rozagel; Rozex; Rozex Gel; Satric; Servizol; Servizole; Supplin; Takimetol; Trichex; Trichozole; Tricowas B; Tricowas-B; Trikacide; Trofonil; Vaginyl; Vagitrix; Vagyl; Zadstat (Foreign brand names outside U.S. in italics) Jackie

Response:

Pregnant – Glucophage or Insulin?

Question:

I’d love to take glucophage, but I don’t want to hurt the baby. Any advice?  Have you ever known anyone to take glucophage while pregnant?

First, congratulations. Second, there was a study in the US using glucophage with women with PCOS…results were regular periods, pregnancies, and successful outcomes to the pregnancies.  As I understand it, the glucophage was continued throughout the pregnancies.  It was briefly reported in Science News and their website for the article includes the e-mail address for the doc involved in the study. http://sciencenews.org/20000513/note2ref.asp Good luck!  I’m very happy for you…just wish that I were in the same position! Carol P.

Response:

There is NO way I’d put a pill in my mouth if pregnant.  They told me that Bendectine was perfectly safe to take for morning sickness, then yanked it off the market the month my twins were born.  One of them was born with a birth defect, and didn’t survive.  Whether it was the medicine or not, I don’t know. But I’d not take any chances.   Bev Remove the "SpamFree" for email, please.  

Response:

First congratulations.  We are expecting our first in a month.   As for you question, I have to say that as far as I know your endocrinologist is right.  According to the glucophage drug manual, and our ob/gyn, glucophage hasn’t been tested for use on pregnant women and insulin is needed .  Ask your ob/gyn to look it up in the PDR. In our 8 months we have had a lot of confusing information, but every one we have had talk too, has told us that sherry cant use glucophage.  I trust our doctor (world renowned high risk pregnancy Ob/Gyn)  and he has made it very clear that glucophage is untested in pregnancy. I will also send you a copy (in a separate e-mail) of the Information packet that glucophage comes with and is located at www.glucophage.com.  If you have an Acrobat Reader you can download it.  The pregnancy part starts on the bottom left column of page 3.  If you can’t download and read it, I have included the relevant part.  I suggest downloading it, highlighting the important part and showing it to your Ob/Gyn  Again congratulations!! glucophage.com says:: Pregnancy Category B. Safety in pregnant women has not been established. Determination of fetal concentrations demonstrated a partial placental barrier to metformin, Because animal reproduction studies are not always predictive of human response, any decision to use this drug should be balanced against the benefits and risks. Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, there is a consensus among experts that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible."

Response:

- Hide quoted text — Show quoted text – I’m 29 years old and have had type 2 diabetes for 8 years.  I found out last week that I am pregnant.  Yay!  :) I’ve been taking glucophage for a few years now and I feel that it’s a miracle drug.  My endocrinologist told me that glucophage hasn’t been tested for use when pregnant and that I’d have to stop taking it and take insulin instead if my sugars should start to rise.  Even without glucophage my blood sugar isn’t that bad (about 86-160), but as this pregnancy progresses it is expected that my readings will get worse and worse.  I’m sad to have to take insulin because it makes me gain weight.  I am a very small eater (I really am.  I eat like I’m a very very skinny person, but I’m not.  I weigh about 280lbs.), but my doctor assures me that I will gain weight on insulin just from my prior experience with it.  I’m very upset to have to get on the vicious circle of extra insulin leading to extra weight leading to worse diabetes leading to extra insulin leading to extra weight, and so on and so on.  The only way I was able to pull out of that cycle in the past was to have gastric bypass surgery, so now I don’t even absorb about 1/3 of the food I eat. Anyway, my ob/gyn says that this is ridiculous.  She says that many women take glucophage while pregnant and that there have never been any birth defects resulting from it. Who should I trust?  The endocrinologist is the head of his department at a large teaching hospital.  The ob/gyn is in a large and successful practice in a good hospital.  Who do I trust? I’d love to take glucophage, but I don’t want to hurt the baby. Any advice?  Have you ever known anyone to take glucophage while pregnant? Thank you for your advice. DaSpida

Glucophage was not tested for pregnant women.  Here is part of the warning: "Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, there is a consensus among experts that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible." You can view the entire PI (prescribing information) at:         http://www.glucophage.com Jude —                  - Coming Soon –  BestOrgs.NET         Oak Park, IL  708-848-0134  URL: http://www.pobox.com/~jcrouch

Response:

Please listen to your endo, if they say no drugs by mouth then follow it.  There is nothing more important now than a healthy baby, and especially not the chance of maybe gaining extra weight from insulin.  I was on hefty doses of insulin when pregnant a couple of times and gained nothing more than baby stuff and weighty boobs – as it should be.  You can always lose extra weight later but you can’t take your baby’s birth defects away once they happen. I don’t know any obs who would even consider giving out drug info to diabetic mums.  I have always been referred straight away to an endo who works hand in hand with the pre natal clinic who in turn follow through with what the endo says. Just by having diabetes alone with pregnanacy you are immediately classified as a high risk patient. – Hide quoted text — Show quoted text – I’m 29 years old and have had type 2 diabetes for 8 years. I found out last week that I am pregnant.  Yay!  :) I’ve been taking glucophage for a few years now and I feel that it’s a miracle drug.  My endocrinologist told me that glucophage hasn’t been tested for use when pregnant and that I’d have to stop taking it and take insulin instead if my sugars should start to rise.  Even without glucophage my blood sugar isn’t that bad (about 86-160), but as this pregnancy progresses it is expected that my readings will get worse and worse.  I’m sad to have to take insulin because it makes me gain weight.  I am a very small eater (I really am.  I eat like I’m a very very skinny person, but I’m not.  I weigh about 280lbs.), but my doctor assures me that I will gain weight on insulin just from my prior experience with it.  I’m very upset to have to get on the vicious circle of extra insulin leading to extra weight leading to worse diabetes leading to extra insulin leading to extra weight, and so on and so on.  The only way I was able to pull out of that cycle in the past was to have gastric bypass surgery, so now I don’t even absorb about 1/3 of the food I eat. Anyway, my ob/gyn says that this is ridiculous.  She says that many women take glucophage while pregnant and that there have never been any birth defects resulting from it. Who should I trust?  The endocrinologist is the head of his department at a large teaching hospital.  The ob/gyn is in a large and successful practice in a good hospital.  Who do I trust? I’d love to take glucophage, but I don’t want to hurt the baby. Any advice?  Have you ever known anyone to take glucophage while pregnant? Thank you for your advice. DaSpida Got questions?  Get answers over the phone at Keen.com. Up to 100 minutes free! http://www.keen.com

Response:

Congratulations! I’m type 1, so I can’t really give you any first hand advice on the glucophage, but reading what other type 2’s in: http://boards.parentsplace.com/messages/get/pppregdiabetic26.html say, it seems that the best choice for you and the baby would seem to be insulin. You’ll be much better able to control the bloodsugars during pregnancy. However I have no answers for you on the weight gain problem. Anyway, take a look in the BB above, it’s specifically meant for pregnant women, with type 1, type 2 or gestational diabetes. Very good for support. Danielle – Hide quoted text — Show quoted text – I’m 29 years old and have had type 2 diabetes for 8 years.  I found out last week that I am pregnant.  Yay!  :) I’ve been taking glucophage for a few years now and I feel that it’s a miracle drug.  My endocrinologist told me that glucophage hasn’t been tested for use when pregnant and that I’d have to stop taking it and take insulin instead if my sugars should start to rise.  Even without glucophage my blood sugar isn’t that bad (about 86-160), but as this pregnancy progresses it is expected that my readings will get worse and worse.  I’m sad to have to take insulin because it makes me gain weight.  I am a very small eater (I really am.  I eat like I’m a very very skinny person, but I’m not.  I weigh about 280lbs.), but my doctor assures me that I will gain weight on insulin just from my prior experience with it.  I’m very upset to have to get on the vicious circle of extra insulin leading to extra weight leading to worse diabetes leading to extra insulin leading to extra weight, and so on and so on.  The only way I was able to pull out of that cycle in the past was to have gastric bypass surgery, so now I don’t even absorb about 1/3 of the food I eat. Anyway, my ob/gyn says that this is ridiculous.  She says that many women take glucophage while pregnant and that there have never been any birth defects resulting from it. Who should I trust?  The endocrinologist is the head of his department at a large teaching hospital.  The ob/gyn is in a large and successful practice in a good hospital.  Who do I trust? I’d love to take glucophage, but I don’t want to hurt the baby. Any advice?  Have you ever known anyone to take glucophage while pregnant? Thank you for your advice. DaSpida Got questions?  Get answers over the phone at Keen.com. Up to 100 minutes free! http://www.keen.com

Response:

I’m 29 years old and have had type 2 diabetes for 8 years.  I found out last week that I am pregnant.  Yay!  :) I’ve been taking glucophage for a few years now and I feel that it’s a miracle drug.  My endocrinologist told me that glucophage hasn’t been tested for use when pregnant and that I’d have to stop taking it and take insulin instead if my sugars should start to rise.  Even without glucophage my blood sugar isn’t that bad (about 86-160), but as this pregnancy progresses it is expected that my readings will get worse and worse.  I’m sad to have to take insulin because it makes me gain weight.  I am a very small eater (I really am.  I eat like I’m a very very skinny person, but I’m not.  I weigh about 280lbs.), but my doctor assures me that I will gain weight on insulin just from my prior experience with it.  I’m very upset to have to get on the vicious circle of extra insulin leading to extra weight leading to worse diabetes leading to extra insulin leading to extra weight, and so on and so on.  The only way I was able to pull out of that cycle in the past was to have gastric bypass surgery, so now I don’t even absorb about 1/3 of the food I eat. Anyway, my ob/gyn says that this is ridiculous.  She says that many women take glucophage while pregnant and that there have never been any birth defects resulting from it. Who should I trust?  The endocrinologist is the head of his department at a large teaching hospital.  The ob/gyn is in a large and successful practice in a good hospital.  Who do I trust? I’d love to take glucophage, but I don’t want to hurt the baby. Any advice?  Have you ever known anyone to take glucophage while pregnant? Thank you for your advice. DaSpida Got questions?  Get answers over the phone at Keen.com. Up to 100 minutes free! http://www.keen.com

Response:

What sleep aids during IVF

Question:

I’m almost certain that melatonin is OUT.

I hear it prevents and hinders ovulation ~`~ Best Wishes That All Of Your Hopes and Dreams Come True ~`~ Cyndie PCOS DES daughter 1ectopic numerous miscarriages Want to Join A PCO and Infertility email support group?? Visit: http://www.geocities.com/pcoifdreams

Response:

s there a place I can find info on risks of certain drugs in pg?  My OB says Zoloft is OK during pg, Id like to see its category! thanks much,

Debbie– there is a PDR online. You can also get a Nursing Drug book at the book store and it will tell you that also. Kristin

Response:

I’d double check on the St John’s Wort – it’s supposed to cause infertility. I would be very cautious before taking it. Pattie 6 years, unexplained 1 m/c Thanksgiving 98 GIFT in June

– Hide quoted text — Show quoted text – Both Valerian and St John’s Wort help with relaxation and drowsiness. Definately check with you dr before taking these though because they can have interactions with drugs and such the same as any other medication.  I do also remember my pharmacist telling me not to take them if I was preg. I know that they both knock me out for about 2 days! :)  (I do have weird dreams when I use it though!) I hope you find something!  I know what those sleepless nights are like! :( Michelle Anyone know if Melatonin would be okay? Valerian is supposed to help with sleep–anyone know if that would be okay? Hugs, Rachel Browne Rachel,         When I cannot sleep I take a herbal tincture of Valerian and Hops which I buy in the UK as Bioforce. It works very well, is non- addictive but as with any herbal product I don’t know what effect (if any) it could have during IVF.  It is worth checking as it is the most effective thing I have found to get me to sleep.  Hope this helps and Good luck. Olivia Ramage

Response:

Great, I guess I am going to be "Sleepless in Oregon" for this IVF! Sigh. Hugs, Rachel – Hide quoted text — Show quoted text – I’m almost certain that melatonin is OUT. I hear it prevents and hinders ovulation ~`~ Best Wishes That All Of Your Hopes and Dreams Come True ~`~ Cyndie PCOS DES daughter 1ectopic numerous miscarriages Want to Join A PCO and Infertility email support group?? Visit: http://www.geocities.com/pcoifdreams

Response:

I will be discussing all of these options with me RE beforehand.  But I bet I am just going to end up sleepless! Hugs, Rachel – Hide quoted text — Show quoted text – I’d double check on the St John’s Wort – it’s supposed to cause infertility. I would be very cautious before taking it. Pattie 6 years, unexplained 1 m/c Thanksgiving 98 GIFT in June Both Valerian and St John’s Wort help with relaxation and drowsiness. Definately check with you dr before taking these though because they can have interactions with drugs and such the same as any other medication.  I do also remember my pharmacist telling me not to take them if I was preg. I know that they both knock me out for about 2 days! :)  (I do have weird dreams when I use it though!) I hope you find something!  I know what those sleepless nights are like! :( Michelle Anyone know if Melatonin would be okay? Valerian is supposed to help with sleep–anyone know if that would be okay? Hugs, Rachel Browne Rachel,         When I cannot sleep I take a herbal tincture of Valerian and Hops which I buy in the UK as Bioforce. It works very well, is non- addictive but as with any herbal product I don’t know what effect (if any) it could have during IVF.  It is worth checking as it is the most effective thing I have found to get me to sleep.  Hope this helps and Good luck. Olivia Ramage

Response:

Thanks, Michelle!  If I do find something that is okay, I will post it here! Hugs, Rachel – Hide quoted text — Show quoted text – Both Valerian and St John’s Wort help with relaxation and drowsiness. Definately check with you dr before taking these though because they can have interactions with drugs and such the same as any other medication.  I do also remember my pharmacist telling me not to take them if I was preg. I know that they both knock me out for about 2 days! :)  (I do have weird dreams when I use it though!) I hope you find something!  I know what those sleepless nights are like! :( Michelle Anyone know if Melatonin would be okay? Valerian is supposed to help with sleep–anyone know if that would be okay? Hugs, Rachel Browne Rachel,         When I cannot sleep I take a herbal tincture of Valerian and Hops which I buy in the UK as Bioforce. It works very well, is non- addictive but as with any herbal product I don’t know what effect (if any) it could have during IVF.  It is worth checking as it is the most effective thing I have found to get me to sleep.  Hope this helps and Good luck. Olivia Ramage

Response:

Hi Cindi, Just checked a couple of sites that have drug info and Ambien is a pregnancy category B–unlikely to harm a baby. Hugs! Rachel Browne – Hide quoted text — Show quoted text – Ambien is a GREAT sleep aid but I understood unsafe during pregnancy so I’ve avoided taking it at all while TTC.  I guess if your RE is rxing it then it must not be as dangerous as I thought — or perhaps leaves the system very rapidly and no trace in case you conceive?? Cindi Hi all, Just thought I would let you know that my RE said no to melatonin, no to antihistamines, no to any herbs, and prescribed me a med called Ambien. He says it is one of the best sleep aids as it doesn’t leave you with that hung-over feeling in the morning and you don’t sleep so deep that nothing will wake you. Hugs, Rachel Browne–day 2 of stims for IVF/ICSI

Response:

Rachel, This is GREAT news.  I’d never take it during pregnancy but glad to know it’s safe while trying (that’s how I look at category B). Cindi – Hide quoted text — Show quoted text – Hi Cindi, Just checked a couple of sites that have drug info and Ambien is a pregnancy category B–unlikely to harm a baby. Hugs! Rachel Browne Ambien is a GREAT sleep aid but I understood unsafe during pregnancy so I’ve avoided taking it at all while TTC.  I guess if your RE is rxing it then it must not be as dangerous as I thought — or perhaps leaves the system very rapidly and no trace in case you conceive?? Cindi Hi all, Just thought I would let you know that my RE said no to melatonin, no to antihistamines, no to any herbs, and prescribed me a med called Ambien. He says it is one of the best sleep aids as it doesn’t leave you with that hung-over feeling in the morning and you don’t sleep so deep that nothing will wake you. Hugs, Rachel Browne–day 2 of stims for IVF/ICSI

Response:

Ambien is a GREAT sleep aid but I understood unsafe during pregnancy so I’ve avoided taking it at all while TTC.  I guess if your RE is rxing it then it must not be as dangerous as I thought — or perhaps leaves the system very rapidly and no trace in case you conceive?? Cindi – Hide quoted text — Show quoted text – Hi all, Just thought I would let you know that my RE said no to melatonin, no to antihistamines, no to any herbs, and prescribed me a med called Ambien. He says it is one of the best sleep aids as it doesn’t leave you with that hung-over feeling in the morning and you don’t sleep so deep that nothing will wake you. Hugs, Rachel Browne–day 2 of stims for IVF/ICSI

Response:

Hi all, Just thought I would let you know that my RE said no to melatonin, no to antihistamines, no to any herbs, and prescribed me a med called Ambien.  He says it is one of the best sleep aids as it doesn’t leave you with that hung-over feeling in the morning and you don’t sleep so deep that nothing will wake you. Hugs, Rachel Browne–day 2 of stims for IVF/ICSI – Hide quoted text — Show quoted text – Hello all, I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative. Anyone know if Melatonin would be okay? As far as herbs go, chamomile doesn’t really do much for me, but Valerian is supposed to help with sleep–anyone know if that would be okay? I am pretty desperate as I cannot imagine trying to do an IVF cycle with little sleep.  Any help would be appreciated. Hugs, Rachel Browne

Response:

I’m so glad you found something!  I had a feeling he would veto the herbs and such! Michelle – Hide quoted text — Show quoted text – Hi all, Just thought I would let you know that my RE said no to melatonin, no to antihistamines, no to any herbs, and prescribed me a med called Ambien. He says it is one of the best sleep aids as it doesn’t leave you with that hung-over feeling in the morning and you don’t sleep so deep that nothing will wake you. Hugs, Rachel Browne–day 2 of stims for IVF/ICSI Hello all, I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative. Anyone know if Melatonin would be okay? As far as herbs go, chamomile doesn’t really do much for me, but Valerian is supposed to help with sleep–anyone know if that would be okay? I am pretty desperate as I cannot imagine trying to do an IVF cycle with little sleep.  Any help would be appreciated. Hugs, Rachel Browne

Response:

Hello all,

Rachel, is that you?  If so, mail me! I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative.

As a chronic non-sleeper at all time but especially during times of stress, I can tell you what I have taken.  I currently take a combination of trazodone, remeron and flexeril.  My doc says all of them are safe for trying to get pregnant, as if.  Anyway, you can ask your RE.  My doc says that sleep is so important that it is better to take the small risk than to go without. *hugs* Louise Taylor

Response:

Both Valerian and St John’s Wort help with relaxation and drowsiness. Definately check with you dr before taking these though because they can have interactions with drugs and such the same as any other medication.  I do also remember my pharmacist telling me not to take them if I was preg. I know that they both knock me out for about 2 days! :)  (I do have weird dreams when I use it though!) I hope you find something!  I know what those sleepless nights are like! :( Michelle – Hide quoted text — Show quoted text – Anyone know if Melatonin would be okay? Valerian is supposed to help with sleep–anyone know if that would be okay? Hugs, Rachel Browne Rachel,         When I cannot sleep I take a herbal tincture of Valerian and Hops which I buy in the UK as Bioforce. It works very well, is non- addictive but as with any herbal product I don’t know what effect (if any) it could have during IVF.  It is worth checking as it is the most effective thing I have found to get me to sleep.  Hope this helps and Good luck. Olivia Ramage

Response:

Hi Baby, http://www.rxlist.com/ is a great site that will tell you lots of things about prescription drugs.  I looked up Zoloft and it is a pg category C.  There was some detailed info about it, but Netscape decided to crash on me, so I didn’t read it. FWIW, the blood pressure meds I take are pg category C. Hugs, Rachel Browne – Hide quoted text — Show quoted text – pregnancy category risk B, is there a place I can find info on risks of certain drugs in pg?  My OB says Zoloft is OK during pg, Id like to see its category! thanks much,                        ~*~      Baby     ~*~           Fly My Angels, Fly, High Up In The Sky       And Look Down On Me Every Now And Then         And Know Im Thinking Of You Every Day…

Response:

pregnancy category risk B,

is there a place I can find info on risks of certain drugs in pg?  My OB says Zoloft is OK during pg, Id like to see its category! thanks much,                        ~*~      Baby     ~*~           Fly My Angels, Fly, High Up In The Sky       And Look Down On Me Every Now And Then         And Know Im Thinking Of You Every Day…

Response:

Hello all, I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative. Anyone know if Melatonin would be okay? As far as herbs go, chamomile doesn’t really do much for me, but Valerian is supposed to help with sleep–anyone know if that would be okay? I am pretty desperate as I cannot imagine trying to do an IVF cycle with little sleep.  Any help would be appreciated. Hugs, Rachel Browne

Response:

I’m almost certain that melatonin is OUT. Ask your RE. I would strongly recommend that you learn some relaxation/breathing techniques.  Also — try Yoga, it really helps relax the body. Hard work, but they really can help, and drugs during IVF just aren’t a good idea. Good luck Jody – Hide quoted text — Show quoted text – Hello all, I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative. Anyone know if Melatonin would be okay? As far as herbs go, chamomile doesn’t really do much for me, but Valerian is supposed to help with sleep–anyone know if that would be okay? I am pretty desperate as I cannot imagine trying to do an IVF cycle with little sleep.  Any help would be appreciated. Hugs, Rachel Browne

Response:

What about gravol?  It’s for nausea, but usually makes people drowsy.  I’ve used it to help me get past severe jet lag.  It’s pregnancy category risk B, same as tylenol.  Although, make sure to ask your doctor first. Sweet dreams, Karen

Response:

– Hide quoted text — Show quoted text -Hello all, I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative. Anyone know if Melatonin would be okay? As far as herbs go, chamomile doesn’t really do much for me, but Valerian is supposed to help with sleep–anyone know if that would be okay? I am pretty desperate as I cannot imagine trying to do an IVF cycle with little sleep.  Any help would be appreciated. Hugs, Rachel Browne

Rachel,         When I cannot sleep I take a herbal tincture of Valerian and Hops which I buy in the UK as Bioforce. It works very well, is non- addictive but as with any herbal product I don’t know what effect (if any) it could have during IVF.  It is worth checking as it is the most effective thing I have found to get me to sleep.  Hope this helps and Good luck. Olivia Ramage

Response:

Hi Karen, Is gravol OTC?  I will ask the RE when I go in next (the 30th) about all these things, but wanted to have some ideas before I went in. Hugs! Rachel – Hide quoted text — Show quoted text – What about gravol?  It’s for nausea, but usually makes people drowsy.  I’ve used it to help me get past severe jet lag.  It’s pregnancy category risk B, same as tylenol.  Although, make sure to ask your doctor first. Sweet dreams, Karen

Response:

Thanks, Olivia!  I will check it out! Hugs, Rachel – Hide quoted text — Show quoted text – Hello all, I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative. Anyone know if Melatonin would be okay? As far as herbs go, chamomile doesn’t really do much for me, but Valerian is supposed to help with sleep–anyone know if that would be okay? I am pretty desperate as I cannot imagine trying to do an IVF cycle with little sleep.  Any help would be appreciated. Hugs, Rachel Browne Rachel,         When I cannot sleep I take a herbal tincture of Valerian and Hops which I buy in the UK as Bioforce. It works very well, is non- addictive but as with any herbal product I don’t know what effect (if any) it could have during IVF.  It is worth checking as it is the most effective thing I have found to get me to sleep.  Hope this helps and Good luck. Olivia Ramage

Response:

Thanks, Jody, but all the relaxation and breathing techniques do nothing for me when I am seriously in the throes of insomnia.  They do help when I am only having a bit of trouble sleeping, though. Hugs, Rachel Browne – Hide quoted text — Show quoted text – I’m almost certain that melatonin is OUT. Ask your RE. I would strongly recommend that you learn some relaxation/breathing techniques.  Also — try Yoga, it really helps relax the body. Hard work, but they really can help, and drugs during IVF just aren’t a good idea. Good luck Jody Hello all, I am an insomniac especially during times of stress.  If I need help, generally, I take benadryl.  I have heard that antihistamines *may* hinder follicle development, so I am looking for an alternative. Anyone know if Melatonin would be okay? As far as herbs go, chamomile doesn’t really do much for me, but Valerian is supposed to help with sleep–anyone know if that would be okay? I am pretty desperate as I cannot imagine trying to do an IVF cycle with little sleep.  Any help would be appreciated. Hugs, Rachel Browne

Response:

What is the new drug out to help with bulimia?

Question:

I know I read a post about a new drug, used for cancer patients, that may also be of use to bulimics.  Today I saw my psychiatrist who upon my suggestion said this drug might be useful for my recovery.  He said that it will not prevent urges, but if I get into a cyclical phase of purging will help me stop the cycle. Just knowing about this new drug gives me a lot of hope — a safety net I hope to not fall back on. Any information on this drug would be greatly appreciated. Ellen

Response:

Hi, Becky, sorry for the ignorance, but I didn’t realize that bulimics felt nausea when they wanted to purge? or am i wrong?

I get nauseated drinking water, for crying out loud.  That’s one reason I started purging in the first place.  I figured if the food felt like it wanted to come up so badly, why not just help it along and get it out of my stomach? Sure, purging for a bulimic is mostly emotional.  I guess.  I mean, when I have gone on an all-out binge and my stomach is so full that I can hardly walk, stand, sit, or lie down, I have to get the food out.  I’d probably end up making a mess all over the rug a bit later if I didn’t go ahead to the bathroom. But I get easily nauseated by even normal amounts of food.  I feel like purging to relieve the feelings of nausea. Just two cents from a girl whose GI system is probably all screwed up anyway. Love, Butterflies ~In the event of rapture, this account will be unmanned.

Response:

Ellen, The vomiting for the Chemo virtually ceased.  I wondered about 7 years ago if this medication would work for bulimics.  It has a calming and ant-nausea effect. It is very expensive (I personally paid off the patent) :) , but may well be worth a try.  From my understanding it helps bulimics to be calmer and less agitated and less nauseated and not feel like they need to vomit.  Sarahrein Justice – When you get what you deserve Mercy – When you don’t get what you deserve Grace – When you get what you don’t deserve "Hunger hurts but starving works when it costs

Response:

Sara, Can you tell me exactly how the drug helped you?  I would appreciate any info. Ellen

Response:

Ellen, One drug is zofran, usually used for nausea with chemo.  It was a wonder drug for me.  Sarah Justice – When you get what you deserve Mercy – When you don’t get what you deserve Grace – When you get what you don’t deserve "Hunger hurts but starving works when it costs

Response:

I know I read a post about a new drug, used for cancer patients, that may also be of use to bulimics.  

It’s called Zofran. VERY expensive, so if you dont have insurance, you should seek out the help of some free meds programs. Nikki "… lost in the darkness of my own circumstance, criticizing echoes leaving me awake in the night… the barrier and blockades that keep me safe and in control while I pretend that I am okay… "

Response:

just a question. it helps bulimics to be calmer and less agitated and less nauseated and not feel like they need to vomit.

sorry for the ignorance, but I didn’t realize that bulimics felt nausea when they wanted to purge? or am i wrong?   b

Response:

Thanks connie for the articles. perhaps the affects that the drug has on seratonin and dopamine (as your info indicated) is one reason it is effective for bulimic patients – since both neurotransmitters play a role. thanks b

Seratonin comes up repeatedly for things that I have dealt with.  When I was young I got severe migraine headaches.  Now, research says there is a seratonin connection.  It also (of course) is part of depression and bulimia (I mean lack of neurotransmitters… I know my paragraph is kind of jumbled but hopefully it makes sense). A long time ago I took L-Tryptophan and that helped.  That effects seratonin.  Doxepin helped… and now, Zoloft helps.  So, for me, there does appear to be a seratonin connection. Kevin K

Response:

just a question. it helps bulimics to be calmer and less agitated and less nauseated and not feel like they need to vomit. sorry for the ignorance, but I didn’t realize that bulimics felt nausea when they wanted to purge? or am i wrong?   b

Just sharing my experience (for what it’s worth)… I never felt nauseaus (ack my spelling is terrible…) when, before, or after purging.  The danger and trap for me is that purging became easy and automatic.  One of the ways bulimia takes hold and became (for me) so hard to give up.  But I did! (thank goodness). Kevin K P.S. — I’m kind of skeptical about a drug for treating bulimia… however, I was skeptical about antidepressants too, so I’ll have an open mind on this one, because antidepressants help me a lot.  I think there is a danger though in relying on meds to do the work of recovery — the real work has to come from making changes.

Response:

it helps bulimics to be calmer and less agitated and less nauseated and not feel like they need to vomit. sorry for the ignorance, but I didn’t realize that bulimics felt nausea when they wanted to purge? or am i wrong?

Ondansetron is usually used in cases of people who are feeling nauseated after chemotherapy for cancer and who want to vomit for that reason;  it is my understanding, too, that when someone is bulimic that there is not that same sensation….  The bulimia is going to stem from more emotional reasons…. Did a little research in Medline and this is what I found, with regards to Ondansetron;  the first article is more generalized with regard to the common usage as an anti-emetic in CA tx, the second is a recent article reviewing the results of an experiment of it being used for bulimia…. and it suggests that there is a physical component in addition to the emotional… Ondansetron / ZofranT Usage Anti Emetic Anti Hallucinating Description: Ondansetron is an oral and parenteral antiemetic agent. It is the first selective serotonin blocking agent to be marketed. It is similar to granisetron, which was marketed in 1994. Ondansetron is an extremely safe and highly effective antiemetic that has greatly improved the ability to give chemotherapy. The quality of life of patients has been tremendously better with ondansetron than with older, traditional antiemetics. Despite its effectiveness, ondansetron is not recommended for the routine treatment of nausea due to its significant cost. Ondansetron was originally approved for the treatment of chemotherapy-induced nausea/vomiting by the FDA in January 1991 and tablets were approved for the treatment of post-operative nausea/vomiting in April 1995. Mechanism of Action: Ondansetron may have central and/or peripheral action. Ondansetron selectively blocks the serotonin 5-HTA receptors. (In contrast, sumatriptan stimulates serotonin receptors, albeit of a different type.) 5-HTA receptors are found centrally in the chemoreceptor trigger zone and peripherally at vagal nerve terminals in the intestines. Whether the action of ondansetron is mediated centrally, peripherally, or a combination of both remains to be determined. Emesis during chemotherapy and radiation therapy appears to be associated with the release of serotonin from enterochromaffin cells in the small intestine. Blocking these nerve endings in the intestines prevents signals to the central nervous system. Ondansetron has no dopamine-receptor blocking activity. Colonic transit time is slowed after multiple oral doses of ondansetron. Pharmacokinetics: Ondansetron is administered orally and parenterally. Oral bioavailability of the tablets is 59%. The drug is also administered by IV infusion. Animal studies indicate that ondansetron has no teratogenic effects and that it is distributed into breast milk. Approximately 36% of an ondansetron dose is distributed into erythrocytes. The drug is about 70-76% bound to plasma protein. Ondansetron undergoes extensive metabolism, mainly by hydroxylation, followed by glucuronide or sulfate conjugation. For adults, the mean elimination half-life is 4 hours; patients under age 15 years show a shorter half-life of about 2.4 hours. Less than 5% of an intravenous dose is eliminated unchanged in the urine. The inactive metabolites are eliminated in the urine. CONTRAINDICATIONS/PRECAUTIONS: Ondansetron is extensively metabolized in the liver and should be used with caution in patients with hepatic disease because of possible increased plasma levels and subsequent toxicity. Patients with compromised liver function should receive no more than 8 mg daily. Ondansetron is classified as pregnancy category B. It should be used during pregnancy only when clearly needed. Ondansetron is excreted into breast milk and should be used with caution during breast-feeding. If use is essential, then alternative methods of feeding are recommended. Ondansetron should be used with caution in patients with granisetron hypersensitivity. Cross-sensitivity is possible between these two agents. The use of ondansetron may mask the symptoms of adynamic ileus or gastric distention after abdominal surgery. DRUG INTERACTIONS: No drug interactions with ondansetron have been identified yet. Because it is metabolized by the cytochrome P-450 system, concern has been expressed about the ability of enzyme inducers to reduce ondansetron’s activity and enzyme inhibitors to increase its toxicity. No such interactions have been reported to date. From a pharmacology perspective, ondansetron and sumatriptan exert opposing effects on serotonin (5-HT) receptors. A specific drug interaction may not occur, however, because ondansetron is an antagonist at the type 3 receptor (5-HTA) while sumatriptan is an agonist at the type 1d serotonin receptor. Neither agent affects other serotonin receptors. ADVERSE REACTIONS: Antagonism of serotonin (5HT) receptors and the subsequent increased levels of serotonin have been hypothesized to increase the risk of developing bronchospasm and/or vasoconstriction. This concern is apparently being realized. As of October 15, 1993, the FDA has received no less than 24 reports of anaphylactoid/anaphylactic reactions to ondansetron injection.DD Manifestations have included angioedema, bronchospasm, dyspnea, hypotension, and/or urticaria. It is not clear at this time if these reactions are due to ondansetron alone or a drug interaction between ondansetron and another chemotherapeutic agent. Other adverse reactions that have been noted during therapy with ondansetron include dizziness (5-41%), constipation (7%), diarrhea (3-13%), hyperbilirubinemia (8-34%), fever, chills, and headache (8-40%). Other adverse effects that occur less frequently include angina, abdominal pain, asthenia and xerostomia. A direct relationship between these effects and ondansetron has not been established, and some of these adverse reactions may result from chemotherapeutic agents or other concomitantly used drugs. In general, ondansetron is well tolerated, with headache being the most troublesome adverse effect. PATIENT INFORMATION: Ondansetron (ZofranT) helps to relieve nausea and vomiting, especially when associated with the treatment of cancer (chemotherapy). Generic ondansetron tablets are not yet available. Before you take ondansetron, your doctor should know if you have any of the following conditions: .liver disease .an unusual or allergic reaction to ondansetron, granisetron, other medicines, foods, dyes, or preservatives .pregnant or trying to get pregnant .breast-feeding Take ondansetron tablets by mouth. Swallow the tablets with a drink of water. The first dose of ondansetron is given 30 minutes before chemotherapy, followed by a dose at regular intervals for one or two days after chemotherapy. Take your doses at regular intervals. Do not take your medicine more often than directed.. Safe use of this medicine for children under 4 years old has not been studied. If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. No interactions have been recorded between ondansetron and other medicines. Tell your doctor or pharmacist: about all other medicines you are taking, including non-prescription medicines; if you are a frequent user of drinks with caffeine or alcohol; if you smoke; or if you use illegal drugs. These may affect the way your medicine works. Check before stopping or starting any of your medicines. Side Effects Serious side effects with ondansetron are uncommon, but severe allergic reactions can occur; they include: .difficulty breathing, wheezing, shortness of breath .fast or irregular heartbeat .tightness in the chest .swelling of the face, tongue, throat, hands and feet Call your doctor as soon as you can if you get any of these side effects. Minor side effects with ondansetron include: .constipation or diarrhea .dry mouth .fainting or lightheadedness .fever, chills .headache .skin rash, itching .stomach pain .tiredness Let your doctor know about these side effects if they do not go away or if they annoy you. Check with your doctor as soon as you can if you have any sign of an allergic reaction. Do not take alcohol while taking ondansetron. Keep out of the reach of children in a container that small children cannot open. Store between 2 and 30C (36 and 86F). Protect from light. Throw away any unused medicine after the expiration date. This article pertains specifically to experiments with Ondansetron and Bulimia: Lancet 2000 Mar 4;355(9206):792-7 Effect of decreasing afferent vagal activity with ondansetron on symptoms of bulimia nervosa: a randomised, double-blind trial. Faris PL, Kim SW, Meller WH, Goodale RL, Oakman SA, Hofbauer RD, Marshall AM, Daughters RS, Banerjee-Stevens D, Eckert ED, Hartman BK Department of Psychiatry, University of Minnesota Medical School, Minneapolis BACKGROUND: Several lines of evidence have led us to postulate that afferent vagal hyperactivity could be an important factor in the pathophysiology of the eating disorder bulimia nervosa. Ondansetron is a peripherally active antagonist of the serotonin receptor 5-HT3, and is marketed for prevention of vagally-mediated emesis caused by cancer chemotherapeutic agents. We investigated the effects of ondansetron on bulimic behaviours in patients with severe and chronic bulimia nervosa in a randomised, double-blind, placebo-controlled study. METHODS: We enrolled patients with severe bulimia nervosa (at least seven coupled binge/vomit episodes per week). The patients were otherwise healthy, their weight was normal, and they were not receiving medical or psychiatric treatment. During the first week of the study, patients recorded all eating-behaviour events to establish a … read more »

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sarah, Becky, sometimes bulimics are very nauseated from screwed up digestion.

yes, but that is true for anorexics and normal people with gi disorders. what I was questioning is a drug’s ability to stop someone from purging when they have binged and are hell-bent on getting it out of their system.   if you have nausea from digestive problems, zofran is not normally a drug of choice – there are other more effective cheaper meds. b

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Becky, sometimes bulimics are very nauseated from screwed up digestion. Sarahrein Justice – When you get what you deserve Mercy – When you don’t get what you deserve Grace – When you get what you don’t deserve "Hunger hurts but starving works when it costs

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Thanks connie for the articles. perhaps the affects that the drug has on seratonin and dopamine (as your info indicated) is one reason it is effective for bulimic patients – since both neurotransmitters play a role. thanks b

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becky when i read that too i had to laugh, about the naseau.  sounded like ignorance on the researchers parts.  i mean for me, one of the biggest benefits when i am on a larger dosage of celexa IS the naseau.  who wants to binge when they already feel like they have a case of the flu?

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and get this, they combined it [Prozac] with buspar and THORAZINE! Whew, a rather potent cocktail, I’d say, especially for a young teen — wow! Thorazine, in and of itself, can be pretty effective…with the other two, also, wow!  Presumably the docs at the facility knew what they were doing and the likely results they would achieve… –Connie

I’d like to think that the presumption is correct, but I’ve seen too many docs who didn’t know what they were doing and the only results they wanted to achieve were to drug the patients so they were more manageable.  A lot easier to do that than deal with real issues.  I have some stories I could tell about what I saw when I was in the psych ward 15 years ago and what happened to some of my friends there, but I’ll spare everyone (and myself dredging up the memories). Kevin K P.S. — there are a lot of doctors that are good, and probably cases where Thorazine is prescribed properly, however it’s also prescribed improperly at times, especially in the "darker ages" of mental health care or by some of the many incompetant doctors who should not be in that profession. P.P.S. — some of the psychiatrists didn’t appear to give a damn about the patients… and it showed.

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If the drug will help with the *mental* urge to force myself to purge, then it will help me, but I’ve taken several "anti nausea" type things, and they don’t work for me because I’ve not been nauseated with bulimia…. I’ve had *real* nausea during pregnancy and flu etc… but every act of purging I’ve ever done since having bulimia has been a conscious choice. Adagio – Hide quoted text — Show quoted text – it’s just like a pdoc saying they do’nt want to give prozac to an anorexic because it reduces appetite – well restriction isn’t about not having an appetite in the first place – not normally. When I was in the hospital back in 1988, Prozac was finally approved for the market, and so the docs there tried to convince me to take it.  At first, I resisted, arguing very much the same thing: "why the heck would you give ME that? I am anorexic!"  Well, they gave it to me and it did have the benefit of helping me not to become so stressed out over the meals and snacks. Even though I wasn’t the least bit hungry (I wouldn’t have been anyway, because of the large amounts and frequency of my snacks and meals), I was surprised at how I didn’t care as much when I had to eat, and was able to cope with the mealtime situation far more easily.  Unfortunately, after I was discharged and at home again, I realized that the Prozac was also too sedating and that it was hampering me in doing some necessary things so I eventually took myself off it.  Since that time, I have not been on any meds. –Connie — "Starving the flesh wastes the spirit." –Kandis Elliot

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have you ever tried effexor?  it’s not a ssri (a lot like one though-works on serotonin, norephinephrine and weakly on dopamine) and sedation is not a big side effect.  it can cause high blood pressure but usually that’s not a problem in people with eating disorders =)

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was discharged and at home again, I realized that the Prozac was also too sedating and that it was hampering me in doing some necessary things so I eventually took myself off it.  Since that time, I have not been on any meds.

I would like to ask something about this. I know that drugs work differently for different people, but does anyone know if there is an SSRI available which is not at all sedating. I used to take Paxil, but found it sedating. I was happy enough on it but too zonked to function properly. I went to my doctor on Monday to ask for something similar, but less sedating. Unfortunately she was on emergency leave and a temporary replacement saw me and said, no, there’s nothing available. Then, after having second thoughts and glancing in her ABC book of drugs, she said she could give me Protryptiline. Like, No Way, that’s a stone-age tricyclic, with more side effects (nasty ones) than any SSRI. Anyway, I need something, I’m just about crawling by from day to day and unable to eat more because that makes me even more depressed. I just wondered if any people with anorexia had had success with any SSRI which is not sedating. I don’t know if my doctor would go as far as prescribing something because I do some research and decide it’s just the thing for me, but she’s usually pretty reasonable, so I could try.  Thanks. BTW, It’s kind of odd that Paxil is often given to anorexics and rarely Prozac since the most common side effect of Paxil is reckoned to be nausea. Pam

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prozac, buspar and thorazine isn’t a bad combo for someone who has a lot of anxiety and ocd type of symptoms.  the antipsychotics are very commonly used as antianxiety drugs and back when prozac came out, they didn’t have the atypicals they do now.

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hi connie, funny, when i was 14, in 1988 and hospitalized they put me on prozac.  i did not want to take it for the opposite reason.  i was afraid it would do just that, make me not want to eat and i would get fat LOL!  my mom says my little brother woudl chase after the carpool down the street because i hadnt taken my pills.  sad huh? but prozac did a whammy on me anyway.  did a reverse side effect and i became veyr suicidal and a self harmer.  was taken off prozac and was okay. and get this, they combined it with buspar and THORAZINE! shell

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it’s just like a pdoc saying they do’nt want to give prozac to an anorexic because it reduces appetite – well restriction isn’t about not having an appetite in the first place – not normally.

When I was in the hospital back in 1988, Prozac was finally approved for the market, and so the docs there tried to convince me to take it.  At first, I resisted, arguing very much the same thing: "why the heck would you give ME that? I am anorexic!"  Well, they gave it to me and it did have the benefit of helping me not to become so stressed out over the meals and snacks. Even though I wasn’t the least bit hungry (I wouldn’t have been anyway, because of the large amounts and frequency of my snacks and meals), I was surprised at how I didn’t care as much when I had to eat, and was able to cope with the mealtime situation far more easily.  Unfortunately, after I was discharged and at home again, I realized that the Prozac was also too sedating and that it was hampering me in doing some necessary things so I eventually took myself off it.  Since that time, I have not been on any meds. –Connie — "Starving the flesh wastes the spirit." –Kandis Elliot

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When I purged I didn’t feel nausea… it was a forced purge

thanks adagio, this is what i thought happened, but didn’t want to assume anything without asking. it’s just like a pdoc saying they do’nt want to give prozac to an anorexic because it reduces appetite – well restriction isn’t about not having an appetite in the first place – not normally.  it’s mind over matter in most cases.  didn’t know if this was the same for purging. thanks to everyone who answered my question. becky

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just a question. it helps bulimics to be calmer and less agitated and less nauseated and not feel like they need to vomit. sorry for the ignorance, but I didn’t realize that bulimics felt nausea when they wanted to purge? or am i wrong?  

When I purged I didn’t feel nausea… it was a forced purge. Adagio

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sorry for the ignorance, but I didn’t realize that bulimics felt nausea when they wanted to purge? or am i wrong?  

hey b, well for me, i NEVER get nauseaus. can’t even remember the last time i felt truly nauseous. in fact don’t even know what it feels like. when i a kid (before i became bulimic) i had gone 10 years without ever getting sick to my stomach before making myself purge. (odd though that even though i never ever get nauseous, it is still incredibly easy for me to purge). funny, last week i was on a 3 hour trip on a very small boat. the seas were incredibly rough. everyone took dramamine except for me (because i honestly WANTED to be nauseous as perhaps it would give me an excuse to purge). everyone else was so seasick an hour into the ride and was hurling over the side of the boat and green, etcetc. i was totally fine. running around on deck, feeling great, actually LOVING the spray of the waves and the excitement. everyone was saying `wow..ag has such an incredibly strong stomach!!! what i would give to be her. if only she knew how horrible throwing up like this was.’ haha. go figure. {{b}} — For info about this service, see http://www.twwells.com/anon/ or e-mail:

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Becky, I think the drug is supposed to help alleviate the urge bulimics experience when overeating, binging or just simply eating.  The need to empty oneself either due to fullness or fear of gaining weight is not as intense. Ellen

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