Generic vs. name brand wellbutrin
Question:
Seizures are not convulsions–sometimes convulsions occur with seizures, other times not, depending on where the seizure occurs–some are undetectable unless one happens to be on an EEG at the time that the seizure occurs. How would you tell if you were having seizures, if you weren’t having convulsions? What might that feel like?
Temporal lobe epilepsy can be hard to diagnose. Some things to look for: spacing out, lapses in consciousness, repetitive stereotyped motor movements (unintentional), frequent (more than a few times a year) deja vu, interpersonal clinginess, preoccupation with "spiritual," hyperverbal or hypergraphic, hyperemotional. None of these things alone necessarily signal seizures but…. It’s hard to diagnose because they often originate from the mesial (inside, proximal to the limbic system) surface of the temporal lobe. In order to be sensed by conventional EEG the electrical has to pass through brain tissue before hit hits the cortex and is often dissipated enough such that it’s hard to record. — When I examine myself and my methods of thought, I come to the conclusion that the gift of fantasy has meant more to me than any talent for abstract, positive thinking. Albert Einstein (1879-1955) Physicist http://home.gwi.net/~mdmpsyd/index.htm
Response:
How would you tell if you were having seizures, if you weren’t having convulsions? What might that feel like? http://www.nlm.nih.gov/medlineplus/ency/article/000696.htm
Thanks, Chris! The description on that page says, both for petit mal and atypical abscence seizures, that there are no consciousness changes, and no memory of the seizure, so unless someone else noticed that you were having them, you’d never know. That’s a bit of an uncomfortable thought, isn’t it? Katherine
Response:
- Hide quoted text — Show quoted text – How would you tell if you were having seizures, if you weren’t having convulsions? What might that feel like? http://www.nlm.nih.gov/medlineplus/ency/article/000696.htm Thanks, Chris! The description on that page says, both for petit mal and atypical abscence seizures, that there are no consciousness changes, and no memory of the seizure, so unless someone else noticed that you were having them, you’d never know. That’s a bit of an uncomfortable thought, isn’t it?
very uncomfortable. I know someone who had been in treatment for anxiety disorder for ages. I eventually got him to go for an EEG (neurologist thought I was imagining things). Not only were seizures found but he’d been having them so long that his right temporal horn had atrophied. And surprise, suprise, once the seizures were treated, his anxiety went away. — When I examine myself and my methods of thought, I come to the conclusion that the gift of fantasy has meant more to me than any talent for abstract, positive thinking. Albert Einstein (1879-1955) Physicist http://home.gwi.net/~mdmpsyd/index.htm
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Huh? NO, it is NOT one of those drugs you can "take in one go if you want"! I’ve got one of the GlaxoSmithKline pamphlets right here, and it says in part: "It is particularly important to administer WELLBUTRIN SR tablets in a manner most likely to minimize the risk of seizure (see WARNINGS)…" "The usual adult target dose for WELLBUTRIN SR Tablets is 300mg/day, given as 150mg twice daily. Dosing with WELLBUTRIN SR Tablets should begin at 150mg/day given as a single daily dose in the morning. If the 150mg initial dose is adequately tolerated, an increase to the 300mg/day target dose, given as 150mg twice daily, may be made as early as day 4 of dosing. There should be an interval of at least 8 hours between sucessive doses
<<… " There’s more, but essentially the pamphlet seems to warn that 200mg at one time is the strongest dose recommended taken at once, up to 400mg a day. Any more runs the risk of overdose – and in studies of the immediate-release version of bupropion, approximately ONE-THIRD of those who overdosed had seizures to some extent or another. They say they haven’t done adequate study on overdoses on the SR version. Barring that study and significantly different results, I’d say it’s FAR safer to assume the relatively HIGH risk of seizure is fairly equivalent across all release formulations of bupropion when taken in amounts exceeding recommendation. — Jon Quixote What is axiomatic frequently isn’t.
– Hide quoted text — Show quoted text – Actually, Wellbutrin os one of the drugs you can take in one go if you want. I currently take 300mg in the morning and 100mg at night and it seems OK Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE This really doesn’t sound like a good idea. The impetus for creating the SR version originally was that standard bupropion (which is what the generic is) caused seizures; although, it should be pointed out that this was at dosages of 600-900 mg/day. The seizure issue had to do with how much and how fast the drug was absorbed, the seizures tending to occur fairly soon after the dose was taken and in greater frequency in people who were bulimic or anorexic. If you want to take the generic, I think it’s probably ok, but I would definitely split the daily dosage into two or three parts. Two drug companies are currently trying to get their generic versions of Wellbutrin SR on the market; I believe the stuff is FDA approved but is being held up by litigation with GlaxoSmithKline. One of the companies, Eon Labs, just had an injunction lifted by a Federal District Court and perhaps will finally get their drug into pharmacies. Todd
Response:
You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand?
Taking more than 150mg at once *can* lead to a seizure. I’ve spent six months taking 200 mg at once, then 100mg later, because I couldn’t manage to keep to a 3x a day schedule. I never had a problem. Oh… by the way. Some people will report that they used to regularly drink a six pack at the bar, and then drive home, and they never got in an accident, right? And that doesn’t mean it wasn’t criminally stupid, and it doesn’t mean they weren’t *damn* lucky to 1) be alive, and 2) not guilty of anyone else’s death. If anyone else drank a six pack and drove home, thinking "well, this other person did it, so it must be okay", you’d call that person "really, really stupid" if you were feeling charitable, right? Well, I hope the parallel here is obvious. I seriously recommend that people *DO NOT* do this. The risk of seizures is greatly reduced if you avoid dumping too much Wellbutrin into the bloodstream at any one time. But, if you took one 100mg standard release, and forgot you took it, and took another, I wouldn’t instantly induce vomiting, or anything. — Everything I needed to know in life I learned in Kindergarten. Like: Beauty has a beginning, and an ending, but always lives beyond its span, in the hearts of many.
Response:
You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand? Taking more than 150mg at once *can* lead to a seizure. I’ve spent six months taking 200 mg at once, then 100mg later, because I couldn’t manage to keep to a 3x a day schedule. I never had a problem.
because you play russian roulette with your brain does not mean others..who perhaps value theirs more highly..should be encouraged to follow suit.. alcohol and bupropion are problematic as far as seizures go doses should NOT be doubled up if missed!!! all in all patients would be far better off following his doctors and pharmacists advice… after all..YOU are not going to be there if he has fits (which can result in permanent damage)..are you? — "Many people would sooner die than think; In fact, they do so." (Bertrand Russell)
Response:
- Hide quoted text — Show quoted text – You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand? Taking more than 150mg at once *can* lead to a seizure. I’ve spent six months taking 200 mg at once, then 100mg later, because I couldn’t manage to keep to a 3x a day schedule. I never had a problem. Oh… by the way. Some people will report that they used to regularly drink a six pack at the bar, and then drive home, and they never got in an accident, right? And that doesn’t mean it wasn’t criminally stupid, and it doesn’t mean they weren’t *damn* lucky to 1) be alive, and 2) not guilty of anyone else’s death.
Some people’s alcohol tolerances are higher than mine or yours. Some people’s livers are better. Beer is mostly water not like liquor for sure. I cannot say what is right for another person however I would not drink a six pack and think I could drive. I’d wait a few hours after drinking two beers eating something and go home when I felt ok. Drinking soda and eating until the food balanced the alcohol and absorbed it so I could go home. That’s just what I think is responsible behavior. If anyone else drank a six pack and drove home, thinking "well, this other person did it, so it must be okay", you’d call that person "really, really stupid" if you were feeling charitable, right? Well, I hope the parallel here is obvious. I seriously recommend that people *DO NOT* do this. The risk of seizures is greatly reduced if you avoid dumping too much Wellbutrin into the bloodstream at any one time. But, if you took one 100mg standard release, and forgot you took it, and took another, I wouldn’t instantly induce vomiting, or anything.
I don’t take wellbutrine I’ve had a seizure in my life so I cannot have any ever at all. I cannot afford another seizure. I can’t take wellbutrine at all because I might have a seizure. – Hide quoted text — Show quoted text – — Everything I needed to know in life I learned in Kindergarten. Like: Beauty has a beginning, and an ending, but always lives beyond its span, in the hearts of many.
Response:
Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE — "To announce that there must be no criticism of the president or that we are to stand by the president right or wrong, is not only unpatriotic and servile, but is morally treasonable to the American public." –Theodore Roosevelt
Response:
That sounds preety dodgy to me. Although I’m not exactly awear of the pharmacokinetics of wellbutrin(bupropion), one of the first things you learn as a pharmacologist is how alted dosing regiems effects blood concentration. If you take several pills at once, you will get a large increase in blood conetration, just after taking the pills, and then this concentration will drop off, until the next dosing. The idea of any dosing regiem is to get as steady a blood conentration as possible. BTW, I was under the impression that bupropion was taken twice daily. Thats not really that big a deal. – Hide quoted text — Show quoted text – Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE
Response:
You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand? — DaveW
– Hide quoted text — Show quoted text – Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE — "To announce that there must be no criticism of the president or that we are to stand by the president right or wrong, is not only unpatriotic and servile, but is morally treasonable to the American public." –Theodore Roosevelt
Response:
Velvet Elvis said… I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff?
I would think that you’d be overdosing if you took your entire daily dosage of standard Wellbutrin (not SR or XL) at one time. Otherwise, why would they bothered to have developed SR for twice a day and and XL for once a day. Casey
Response:
You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand?
Ummm Wellbutrin SR is in a dose higher than that. The delivery mechanism is different than in regular tablets. As far as convulsions, bupropion is one of the worse in terms of lowering seizure threshold but most of the documented seizure activity was at (over) doses of around 2,000 miligrams — When I examine myself and my methods of thought, I come to the conclusion that the gift of fantasy has meant more to me than any talent for abstract, positive thinking. Albert Einstein (1879-1955) Physicist http://home.gwi.net/~mdmpsyd/index.htm
Response:
Velvet Elvis said… – Hide quoted text — Show quoted text – Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE
I think your doctor got it wrong. I don’t think you should take the regular type of Wellbutrin all at once. Some people like the 3x a day style of Wellbutrin better. I would just take them 3x a day and live with it. You can take them with or without food, so I don’t see the problem.
Response:
You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand?
umm, this is an extremely overly cautious statement. The dosage at which convulsions were recorded was in the magnitude of 2,000 mg. 300 mg of bupropion in someone with a known seizure disorder isn’t a good idea (hell, 150 mg isn’t) but in the absence of a seizure disorder, it’s extremely improbable that it will induce a seizure. And his (?) psychiatrist does probably know that. — When I examine myself and my methods of thought, I come to the conclusion that the gift of fantasy has meant more to me than any talent for abstract, positive thinking. Albert Einstein (1879-1955) Physicist http://home.gwi.net/~mdmpsyd/index.htm
Response:
- Hide quoted text — Show quoted text – Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE
This really doesn’t sound like a good idea. The impetus for creating the SR version originally was that standard bupropion (which is what the generic is) caused seizures; although, it should be pointed out that this was at dosages of 600-900 mg/day. The seizure issue had to do with how much and how fast the drug was absorbed, the seizures tending to occur fairly soon after the dose was taken and in greater frequency in people who were bulimic or anorexic. If you want to take the generic, I think it’s probably ok, but I would definitely split the daily dosage into two or three parts. Two drug companies are currently trying to get their generic versions of Wellbutrin SR on the market; I believe the stuff is FDA approved but is being held up by litigation with GlaxoSmithKline. One of the companies, Eon Labs, just had an injunction lifted by a Federal District Court and perhaps will finally get their drug into pharmacies. Todd
Response:
You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand? umm, this is an extremely overly cautious statement. The dosage at which convulsions were recorded was in the magnitude of 2,000 mg. 300 mg of bupropion in someone with a known seizure disorder isn’t a good idea (hell, 150 mg isn’t) but in the absence of a seizure disorder, it’s extremely improbable that it will induce a seizure. And his (?) psychiatrist does probably know that.
If this is the same DaveW that I’ve seen on other groups I can’t figure out if he’s a fourth-rate troll or just a garden variety ignoramus. I’ve _never_ seen him get anything right. Wellbutrin lowers the seizure threshold. The limit value was set based on clinical trials to a level that minimized the number of individuals in whom seizures would occur. Some very small percentage of individuals will experience seizures at the limit dosage, others won’t at considerably higher dosages. Seizures are not convulsions–sometimes convulsions occur with seizures, other times not, depending on where the seizure occurs–some are undetectable unless one happens to be on an EEG at the time that the seizure occurs. — –John Reply to jclarke at ae tee tee global dot net (was jclarke at eye bee em dot net)
Response:
I take standard Wellbutrin 3 times a day, and I have missed a dose before. Like an idiot I took the dose I missed with the next dose, and got some real stomach trouble in return. Extended release and timed release tablets are a days dose you take in one pill. The coating on an SR/XR has different thicknesses for each dose of medication in the pill. If the pill has 3 doses, the coating on 1/3 of the pill dissolves when you take it, the coating on the next dose, takes 4 hours to dissolve, and the last dose takes 8 hours to dissolve and start working. Even though an SR/XR is more than one dose, you only get one dose at a time from it. Most of the time an SR/XR has been introduced to the market, so the manufacture can renew there patent on the medication, preventing anyone from producing it in a generic. DjD
– Hide quoted text — Show quoted text – Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE — "To announce that there must be no criticism of the president or that we are to stand by the president right or wrong, is not only unpatriotic and servile, but is morally treasonable to the American public." –Theodore Roosevelt
Response:
I take standard 150mg Wellbutrin, and 30mgs of Dexedrine, 3 times a day. I also take 1200mgs of Lithium a day, for rapid cycling bipolar disorder, on top of my ADD. I have a seizure disorder, and take high doses of Wellbutrin and Dexedrine, and they haven’t caused me any seizer trouble. DjD
– Hide quoted text — Show quoted text – You CANNOT take more than a MAXIMUM of 150mg of Wellbutrin any more often than once every four hours. Taking more than 150mg at once leads to convulsions! Your psychiatrist should know this. Did you misunderstand? umm, this is an extremely overly cautious statement. The dosage at which convulsions were recorded was in the magnitude of 2,000 mg. 300 mg of bupropion in someone with a known seizure disorder isn’t a good idea (hell, 150 mg isn’t) but in the absence of a seizure disorder, it’s extremely improbable that it will induce a seizure. And his (?) psychiatrist does probably know that. — When I examine myself and my methods of thought, I come to the conclusion that the gift of fantasy has meant more to me than any talent for abstract, positive thinking. Albert Einstein (1879-1955) Physicist http://home.gwi.net/~mdmpsyd/index.htm
Response:
Seizures are not convulsions–sometimes convulsions occur with seizures, other times not, depending on where the seizure occurs–some are undetectable unless one happens to be on an EEG at the time that the seizure occurs.
How would you tell if you were having seizures, if you weren’t having convulsions? What might that feel like? Katherine
Response:
Seizures are not convulsions–sometimes convulsions occur with seizures, other times not, depending on where the seizure occurs–some are undetectable unless one happens to be on an EEG at the time that the seizure occurs. How would you tell if you were having seizures, if you weren’t having convulsions? What might that feel like? Katherine
http://www.nlm.nih.gov/medlineplus/ency/article/000696.htm
Response:
Actually, Wellbutrin os one of the drugs you can take in one go if you want. I currently take 300mg in the morning and 100mg at night and it seems OK
– Hide quoted text — Show quoted text – Howdy. I had a psychiatrist’s appointment yesterday. I mentioned that I’d lost my health insurance and asked if I could switch to generic Prozac from celexa. After OKing this, he suggested I go with generic Wellbutrin as well. I have been taking Wellbutrin SR, 150mgs 2x a day. I responded that I’d like to save the money, but didn’t like the idea of going on something that has to be taken several times a day, as the SR preparation of Wellbutrin is not available in a generic. He responded that he was pretty sure I could take the whole dose of standard Wellbutrin once a day and not worry about it. Has anyone else tried this? Does taking standard Wellbutrin in one large dose a day work any differently than taking smaller doses several times a day? How does the standard compare to the SR and XR? For that matter, how does the generic compare to the name brand stuff? Anyone have any experience with this? thanks, VE This really doesn’t sound like a good idea. The impetus for creating the SR version originally was that standard bupropion (which is what the generic is) caused seizures; although, it should be pointed out that this was at dosages of 600-900 mg/day. The seizure issue had to do with how much and how fast the drug was absorbed, the seizures tending to occur fairly soon after the dose was taken and in greater frequency in people who were bulimic or anorexic. If you want to take the generic, I think it’s probably ok, but I would definitely split the daily dosage into two or three parts. Two drug companies are currently trying to get their generic versions of Wellbutrin SR on the market; I believe the stuff is FDA approved but is being held up by litigation with GlaxoSmithKline. One of the companies, Eon Labs, just had an injunction lifted by a Federal District Court and perhaps will finally get their drug into pharmacies. Todd
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